Serum metabolomics reveals the anti-aging effect of royal jelly in D-galactose induced aging mice
文献类型： 外文期刊
第一作者： Hu, Han
作者： Hu, Han;Lv, Guoda;Wei, Qiaohong;Liu, Xizi;Han, Bin;Wu, Fan;Chao, Xuyuan
作者机构：
关键词： Royal jelly; Anti-aging; Essential amino acid; Lipid; Nucleotide; Functional food
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.0； 五年影响因子：4.9 ）
ISSN： 1756-4646
年卷期： 2024 年 123 卷
页码：
收录情况： SCI
摘要： Aging, marked by a gradual decline in physiological functions, presents significant global health challenges. While royal jelly (RJ) is known for its biological activities, its anti-aging mechanisms require further investigation. Using a D-galactose (D-gal)-induced aging mouse model, this study applied untargeted serum metabolomics to explore RJ's effects. RJ administration significantly (P < 0.05) improved locomotor and cognitive abilities impaired by D-gal-induced aging. Metabolomic analysis showed that RJ modulates key pathways in amino acid, lipid, and nucleotide metabolism, which are essential for cellular function and energy supply. RJ enhanced the tricarboxylic acid cycle (P < 0.05), increased essential amino acids, and elevated nucleotide availability, supporting cognitive function and energy metabolism in aging mice. Notably, RJ had a stronger effect on male mice, particularly in improving lipid and nucleotide metabolism. These findings highlight RJ's potential as a promising anti-aging intervention, warranting further investigation for therapeutic applications in aging.
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