High Expression Level of alpha 2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection

文献类型： 外文期刊

第一作者： Ding, Li

作者： Ding, Li;Sun, Siyue;Chen, Xiangqin;Zhang, Tiantian;Cheng, Hongwei;Hao, Jiayue;Lu, Yunhua;Li, Zheng;Cheng, Yimin;Guo, Wei;Wang, Xiurong

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关键词： breastfeeding women; saliva; sialic acids (Sia); avian influenza virus (AIV); glycoprotein

期刊名称：MOLECULES （ 影响因子：4.927； 五年影响因子：5.11 ）

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年卷期： 2022 年 27 卷 13 期

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收录情况： SCI

摘要： Terminal sialic acids (Sia) on soluble glycoprotein of saliva play an important role in the clearance of influenza virus. The aim of this study is to investigate the alteration of sialylation on the salivary proteins of women during the lactation period and its effect on the saliva binding ability to virus. In total, 210 saliva samples from postpartum women with and without breastfeeding were collected, and the expression level of alpha 2-3/6-linked Sia on the whole salivary proteins and specific glycoproteins of IgA and MUC5B from different groups were tested and verified using lectin microarray, blotting analysis and ELISA based method. The H1N1 vaccine and three strains of Avian influenza virus (AIV) were used for the saliva binding assay. Results showed that the variation in salivary expression level of alpha 2-3-linked Sia was much more obvious than the alpha 2-6-linked Sia, which was up-regulated significantly in the breastfeeding groups compared to the non-breastfeeding groups at the same postpartum stage. Furthermore, the binding abilities of salivary glycoproteins to AIV strains and H1N1 vaccine were increased in breastfeeding groups accordingly. This finding adds new evidence for the maternal benefit of breastfeeding and provides new thinking to protect postpartum women from AIV infection.

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