Dauriporphine inhibited lung cancer cell viability, motility, and energy metabolism through the miR-424-5p/MAPK14 axis

文献类型： 外文期刊

第一作者： Du, Yan-Jia

作者： Du, Yan-Jia;Fu, Yao;Lan, Meng;Zhang, Hui;Wu, Nan;Du, Yan-Jia;Lan, Meng;Wu, Nan;Lv, Jin-Peng;Li, Jing-Feng

作者机构：

关键词： Anti-lung cancer treatment; Dauriporphine; Cell viability; Cell motility; Energy metabolism

期刊名称：HEREDITAS （ 影响因子：2.5； 五年影响因子：2.6 ）

ISSN： 1601-5223

年卷期： 2025 年 162 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundDauriporphine is a major ingredient of Manispernum daericum DC., which has been demonstrated to show wide anti-tumor activities. miR-424-5p, as a regulator of lung cancer, was hypothesized to serve as the therapeutic target for dauriporphine This study evaluated the potential of dauriporphine in treating lung adenocarcinoma and revealed the underlying molecular mechanism.ResultsThe anti-tumor effect of dauriporphine on lung adenocarcinoma was assessed in A549 cells, and it was found that dauriporphine significantly inhibited the viability of A549 cells in a concentration-dependent manner with the half maximal inhibitory concentration (IC50) value of 10.57 mu M. Dauriporphine induced decreasing cell growth, motility, and energy metabolism, indicating the anti-tumor effect of dauriporphine on A549 cells. Dauriporphine inducing elevated miR-424-5p levels, while silencing miR-424-5p significantly recovered cell viability, migration, and energy metabolism of A549 cells. Mitogen-activated protein Kinase 14 (MAPK14) was negatively regulated by miR-424-5p, and the knockdown of MAPK14 could reverse the protective effect of miR-424-5p on dauriporphine-treated A549 cells.ConclusionDauriporphine inhibited cell growth, metastasis, and glycolysis-related energy metabolism of lung adenocarcinoma cells via modulating miR-424-5p/MAPK14 axis. Dauriporphine can be considered in drug development for lung adenocarcinoma.Clinical trial numberNot applicable.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序