Editing Plant Volatile Isoeugenol for Integrated Aphid Management: Discovering Ecofriendly Insect Behavioral Regulators with Push-Pull Activity Targeting Odorant-Binding Proteins

文献类型： 外文期刊

第一作者： Liu, Yan

作者： Liu, Yan;Chen, Chen;Zhang, Yimeng;Huang, Jiachuan;Pan, Shixiang;Yang, Zhaokai;Shi, Zhuo;Yang, Xinling;Qu, Cheng;Huang, Yiwen;Qin, Yaoguo;Huang, Yiwen;Qin, Yaoguo;Li, Xuesheng

作者机构：

关键词： insect behavioral regulator; "push-pull"strategy; odorant-binding proteins; ecofriendlybotanical derivatives; molecular docking; densityfunctional theory

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 33 期

页码：

收录情况： SCI

摘要： Chemical ecology-based insect behavioral regulation approaches, particularly the "push-pull" strategy, hold tremendous potential for sustainable pest management. Odorant-binding proteins (OBPs) are key targets for regulating insect behavior, whereas plant volatile organic compounds function as key semiochemicals. A series of isoeugenol derivatives were rationally edited by targeting Acyrthosiphon pisum OBP9 and Harmonia axyridis OBP15 for discovering botanical-based insect behavioral regulators. Most derivatives demonstrated significantly higher target binding activity than isoeugenol, with compound I-10 showing exceptional bioactivity. I-10 displayed excellent A. pisum-repellent and H. axyridis-attractive activities. Molecular mechanism studies established the superior binding ability of I-10 to both OBPs via hydrophobic interactions, with its high chemical softness, large hydrophobic surface area, and extensive charge distribution contributing to its bioactivity. Importantly, I-10 showed favorable biosafety for honeybees, ladybugs, parasitic wasps, and plants. This study provides novel insights for developing ecofriendly candidates with push-pull activity by targeting OBPs for integrated aphid management.

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