Pharmacokinetics of florfenicol and its metabolite florfenicol amine in the plasma, urine, and feces of fattening male donkeys following single oral administration

文献类型： 外文期刊

第一作者： Liu, Shijie

作者： Liu, Shijie;Guo, Yanxin;Qu, Honglei;Fu, Tianze;Kang, Ruifen;Cheng, Jie;Huang, Shimeng;Zhao, Lihong;Ma, Qiugang;Qu, Honglei;Cheng, Jie;Dong, Yanjie;Zhao, Shancang

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关键词： florfenicol; florfenicol amine; pharmacokinetics; donkey; urinary excretion; antibiotic

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）

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年卷期： 2024 年 10 卷

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收录情况： SCI

摘要： Florfenicol (FF) is a commonly used antibacterial agent in animals. We investigated the pharmacokinetics of FF and its metabolite florfenicol amine (FFA) in donkeys. Donkeys were administered FF (30 mg/kg bodyweight, p.o.). Pharmacokinetic parameters were calculated using a non-compartmental model. The FF (FFA) pharmacokinetics parameters were characterized by along elimination half-life (t1/2 kz) of 5.92 h (15.95 h), plasma peak concentration (Cmax) of 0.13 mu g/mL (0.08 mu g/mL), and the time taken to reach Cmax (Tmax) of 0.68 h (0.72 h). The area under plasma concentration-time curve and mean residence time of FF (FFA) in plasma were 1.31 mu g center dot mL-1 center dot h (0.47 mu g center dot mL-1 center dot h) and 10.37 h (18.40 h), respectively. The t1/2 kz of FF and FFA in urine was 21.93 and 40.26 h, and the maximum excretion rate was 10.56 and 4.03 mu g/h reached at 25.60 and 32.20 h, respectively. The respective values in feces were 0.02 and 0.01 mu g center dot h-1 reached at 33.40 h. The amount of FF and FFA recovered in feces was 0.52 and 0.22 mu g, respectively. In conclusion, FF (FFA) is rapidly absorbed and slowly eliminated after a single oral administration to donkeys. Compared to FF, FFA was more slowly eliminated. FF (FFA) is mostly excreted through urine.

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