A tailored nanocarrier DMON and CpGs synergistically drive the formulation of a highly immunogenic and long-acting vaccine against echinococcosis

文献类型： 外文期刊

第一作者： Xin, Ting

作者： Xin, Ting;Ding, Jiabo;Gao, Xintao;Zhou, Chenghao;Zhang, Zhifang;Li, Yinue;Tao, Siyi;Ru, Jiaxi

作者机构：

关键词： Nanocarrier; DMON nanoparticle; CpG adjuvants; Vaccine; Echinococcosis; Early; robust and long-lasting immunity

期刊名称：MATERIALS TODAY BIO （ 影响因子：10.2； 五年影响因子：10.2 ）

ISSN： 2590-0064

年卷期： 2025 年 32 卷

页码：

收录情况： SCI

摘要： Hydatid disease (echinococcosis) is a zoonotic parasitic disease that seriously endangers human health and livestock production. To develop a safer, more effective vaccine with an exceptionally long-lasting immune response, we employed an 'all-in-one' strategy to construct a nanovaccine against echinococcosis. In this system, a dendritic mesoporous organosilica nanoparticle (DMON), Eg95 antigen, and two types of CpG potentiators (CpG ODN and pCpG) were integrated into a single nanoplatform. Compared to the commercial Quil-Aformulated vaccine, these two nanovaccines exhibited significant advantages in inducing early, robust, and long-lasting protective immune responses, especially in terms of IgG1 antibody responses and Th1 cytokine TNF alpha secretion. Notably, the certain adjuvant combination (DMON + pCpG) formulated-vaccine Eg95N + pCpG@DMON conferred stronger adjuvanticity to the antigen than Quil-A during the late stage (42-84 days). Systematic evaluation demonstrated excellent biodegradability and biosafety of DMON and its-based vaccine. This research provides a strong foundation for upgrading vaccines against echinococcosis.

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