A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation at genes but not TEs in Arabidopsis

文献类型： 外文期刊

第一作者： Zhou, Xishi

作者： Zhou, Xishi;Zhu, Yiwang;He, Yuhan;Zhang, Cui-Jun;He, Junna;He, Junna;Tang, Kai;Zhu, Mingku;Wang, Xingang;Zhang, Lingrui;Velanis, Christos N.;Graser, Lisa;de Leau, Erica;Goodrich, Justin;Tang, Kai;Zhu, Jian-Kang;Zhang, Cui-Jun;Tang, Kai;Zhu, Jian-Kang;Zhang, Cui-Jun;Zhu, Mingku;Graser, Lisa;Andy Tao, W.

作者机构：

关键词： deacetylation; flowering; Harbinger; HDA6; histone acetylation; protein complex; SANT

期刊名称：JOURNAL OF INTEGRATIVE PLANT BIOLOGY （ 影响因子：7.061； 五年影响因子：6.002 ）

ISSN： 1672-9072

年卷期： 2021 年 63 卷 8 期

页码：

收录情况： SCI

摘要： In eukaryotes, histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional activation. HDA6 is a histone deacetylase involved in the transcriptional regulation of genes and transposable elements (TEs) in Arabidopsis thaliana. HDA6 has been shown to participate in several complexes in plants, including a conserved SIN3 complex. Here, we uncover a novel protein complex containing HDA6, several Harbinger transposon-derived proteins (HHP1, SANT1, SANT2, SANT3, and SANT4), and MBD domain-containing proteins (MBD1, MBD2, and MBD4). We show that mutations of all four SANT genes in the sant-null mutant cause increased expression of the flowering repressors FLC, MAF4, and MAF5, resulting in a late flowering phenotype. Transcriptome deep sequencing reveals that while the SANT proteins and HDA6 regulate the expression of largely overlapping sets of genes, TE silencing is unaffected in sant-null mutants. Our global histone H3 acetylation profiling shows that SANT proteins and HDA6 modulate gene expression through deacetylation. Collectively, our findings suggest that Harbinger transposon-derived SANT domain-containing proteins are required for histone deacetylation and flowering time control in plants.

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