Preparation and applications of metal-organic frameworks in chiral chromatographic separation

文献类型： 外文期刊

第一作者： Tang, Tao

作者： Tang, Tao;Luo, Yongqi;Zhang, Xinglong;Zhu, Zhiyi;Wang, Yuchen;Zhang, Suoying;Zhang, Weina;Luo, Yongqi;Zhang, Xinglong;Zhu, Zhiyi;Wang, Yuchen;Zhang, Suoying;Zhang, Weina;Gu, Zhida;Gu, Zhida

作者机构：

关键词： Metal-organic frameworks; Chiral stationary phase; Chiral chromatography; Enantiomeric separation

期刊名称：TRAC-TRENDS IN ANALYTICAL CHEMISTRY （ 影响因子：11.8； 五年影响因子：12.7 ）

ISSN： 0165-9936

年卷期： 2024 年 179 卷

页码：

收录情况： SCI

摘要： Separating pure enantiomers from racemates has long been a challenging and significant task across various scientific disciplines of biology, medicine, and chemistry. Over the past two decades, metal-organic frameworks (MOFs) have emerged as one of the most sought-after materials, showcasing unparalleled advantages in various applications. Chiral MOFs, in particular, have garnered increasing attention in enantiomeric separation. Unlike conventional materials, MOFs offer greater potential for achieving enantiomeric separation in chromatographic techniques due to their customizable chiral structures and adjustable pore environments. In this review, we aim to outline the remarkable progress and achievements of MOFs as stationary phases in the field of chromatographic enantiomeric separation including gas chromatography, high-performance liquid chromatography, and capillary electrochromatography. The discussions about MOF synthesis, column packing strategy, and MOFbased column performance, will improve our understanding about the design, immobilization, and separation mechanism for the MOF stationary phase. In addition, we explore the benefits, constraints, and future possibilities of these applications.

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