Screening, identification, and application of aptamers against allergens in food matrices

文献类型： 外文期刊

第一作者： Zhu, Chao

作者： Zhu, Chao;Du, Hongxia;Liu, Hao;Qin, Hongwei;Yan, Mengmeng;Li, Linsen;Qu, Feng

作者机构：

关键词： Food allergen; aptamer; SELEX; aptasensor; allergy inhibitor

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：8.8； 五年影响因子：12.0 ）

ISSN： 1040-8398

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Food allergies have become one of the most pressing issues in food safety and public health globally along with their incidence increasing in recent years. The reliable recognition of allergens from different sources, especially food-hidden allergens, is essential for preventing and controlling food allergies. Recently, aptamers, as emerging recognition elements, have gained considerable attention in food allergy, especially in the detection of food allergens. This review systematically summarizes the latest progress in screening, identification, and application of aptamers against food allergens over the past five years. We first introduce a brief overview of food allergy and aptamers, followed by a detailed focus on the aptamers' research against different food allergens broadly based on the major categories of the Big-8 allergens: highlighting the newly screened aptamers and their applied systematic evolution of ligands by exponential enrichment (SELEX) strategies, and emphasizing their practical applications including aptasensors, allergy inhibitors, or affinity adsorptions. Finally, the remaining challenges and future exploitations faced by aptamers in food allergens are comprehensively discussed and depicted. This review holds the promise of inspiring a broader range of researchers to gain an in-depth understanding of food allergy assisted by aptamer recognition and to facilitate improved biochemical analyses and successful application.

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