Humic acids alleviate aflatoxin B1-induced hepatic injury by reprogramming gut microbiota and absorbing toxin

文献类型： 外文期刊

第一作者： Xu, Pengfei

作者： Xu, Pengfei;Dong, Shenghui;Luo, Xinyuan;Ji, Xinyao;Zhang, Jing;Meng, Guangfan;Zhang, Jie;Wei, Bin;Zhang, Cong;Zhu, Xiaoling;Jia, Baolei

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关键词： Humic substance; AFB1; Intestine; Liver; Gut barrier functions; Mice

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 259 卷

页码：

收录情况： SCI

摘要： Aflatoxin B1 (AFB1) is a hepatotoxic fungal metabolite that is widely present in food and can cause liver cancer. As a potential detoxifier, naturally occurring humic acids (HAs) may be able to reduce inflammation and restructure the gut microbiota composition; however, little is known about the mechanism of HAs detoxification as applied to liver cells. In this study, HAs treatment alleviated AFB1-induced liver cell swelling and the infiltration of inflammatory cells. HAs treatment also reinstated various enzyme levels in the liver disturbed by AFB1 and substantially alleviated AFB1-caused oxidative stress and inflammatory responses by enhancing immune functions in mice. Moreover, HAs increased the length of the small intestinal and villus height to restore intestinal permeability, which is impaired by AFB1. In addition, HAs reconstructed the gut microbiota, increasing the relative abundance of Desulfovibrio, Odoribacter, and Alistipes. In vitro and in vivo assays demonstrated that HAs could efficiently remove AFB1 by absorbing the toxin. Therefore, HAs treatment can ameliorate AFB1induced hepatic injury by enhancing gut barrier function, regulating gut microbiota, and adsorbing toxin.

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