Nanocomposites of boronic acid-functionalized magnetic multi-walled carbon nanotubes with flexible branched polymers as a novel desorption/ionization matrix for the capture and direct detection of cis-diol-flavonoid compounds coupled with MALDI-TOF-MS

文献类型： 外文期刊

第一作者： Li, FuKai

作者： Li, FuKai;Wang, Min;Zhou, Jian;Yang, MengRui;Wang, TongTong;Li, FuKai;Wang, Min;Zhou, Jian;Yang, MengRui;Wang, TongTong

作者机构：

关键词： Flavonoids; Boronic acid; MALDI-TOF-MS; Small biomolecules; Nanocomposite

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：14.224； 五年影响因子：12.984 ）

ISSN： 0304-3894

年卷期： 2022 年 429 卷

页码：

收录情况： SCI

摘要： Novel boronic acid-functionalized magnetic multi-walled carbon nanotubes with flexible branched polymer (Fe3O4@MWCNTs@epsilon-PL@BA) nanocomposites were fabricated and applied as the desorption/ionization matrix for the MALDI-TOF-MS determination of low molecular weight flavonoids. The prepared nanocomposite was systematically characterized by various techniques. Compared to the traditional organic matrix, the proposed Fe3O4@MWCNTs@epsilon-PL@BA matrix has excellent ionization efficiency and low-background noise interference due to the MWCNTs unique electron-phonon interaction and the high introduction density of bomnic acid functional groups. Good sensitivity and ultra-high salt tolerance of the Fe3O4@MWCNTs@epsilon-PL@BA-assisted MALDI-TOF-MS were permitted for the determination and quantification of flavonoids in actual samples. Noticeably, the limits of detection (LODs) for the target flavonoids were in the range 17-33 nM. The relative standard deviations (RSDs) of spot-to-spot and sample-to-sample (n = 10) were <= 9.8% and <= 10.1%, respectively. Furthermore, the wide linear ranges (0.1 - 500 mu g/mL) and satisfactory calibration plot coefficients (R-2 > 0.99) of flavonoids were achieved by MALDI-TOF-MS with the Fe3O4@MWCNTs@epsilon-PL@BA matrix. Good recoveries (92-105.5%) were achieved for the target flavonoids in practical food samples. Hence, the prepared Fe3O4@MWCNTs@epsilon-PL@BA nanocomposites have applications in the selective and efficient capture of target flavonoids active biomolecules coupled with MALDI-TOF-MS determination in actual samples.

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