Cobalt-catalyzed chemoselective dehydrogenation through radical translocation under visible light

文献类型： 外文期刊

第一作者： Yu, Wan-Lei

作者： Yu, Wan-Lei;Ren, Zi-Gang;Ma, Ke-Xing;Yang, Jun-Jie;Xu, Peng-Fei;Zheng, Haixue;Xu, Peng-Fei;Yang, Hui-Qing;Yu, Wan-Lei;Wu, Wangsuo;Xu, Peng-Fei

作者机构：

期刊名称：CHEMICAL SCIENCE （ 影响因子：9.969； 五年影响因子：9.974 ）

ISSN： 2041-6520

年卷期： 2022 年 13 卷 26 期

页码：

收录情况： SCI

摘要： The transformations that allow the direct removal of hydrogen from their corresponding saturated counterparts by the dehydrogenative strategy are a dream reaction that has remained largely underexplored. In this report, a straightforward and robust cobaloxime-catalyzed photochemical dehydrogenation strategy via intramolecular HAT is described for the first time. The reaction proceeds through an intramolecular radical translocation followed by the cobalt assisted dehydrogenation without needing any other external photosensitizers, noble-metals or oxidants. With this approach, a series of valuable unsaturated compounds such as alpha,beta-unsaturated amides, enamides and allylic and homoallylic sulfonamides were obtained in moderate to excellent yields with good chemo- and regioselectivities, and the synthetic versatility was demonstrated by a range of transformations. And mechanistic studies of the method are discussed.

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