Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

文献类型： 外文期刊

第一作者： Li, Hui

作者： Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Mi, Jia;Lu, Lu;Yan, Yamei

作者机构：

关键词： Lycium ruthenicum Murray; female obesity; gut microbiota; bile acid metabolism

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：1.8； 五年影响因子：1.5 ）

ISSN： 1934-578X

年卷期： 2024 年 19 卷 4 期

页码：

收录情况： SCI

摘要： Objectives: Female obesity may be improved by the consumption of a high-polyphenolic-rich diet. Lycium ruthenicum Murray is a renowned edible plant, the fruit of which is abundant in anthocyanins and exhibits many biological activities. This study aimed to investigate the potential impact of anthocyanins derived from Lycium ruthenicum Murray (ACN) intervention on improving obesity by regulating the gut microbiota and bile acids (BAs) metabolism in high-fat diet (HFD)-induced female mice. Methods: A total of 32 C57BL/6J female mice were divided into four distinct groups: the Ctrl group (fed a normal diet), Ctrl + ACN group (fed a normal diet plus 8 mg/mL extract of ACN), HFD group (fed a high-fat diet), and HFD + ACN group (fed a HFD plus 8 mg/mL extract of ACN). Results: The findings showed that ACN significantly reduced the body weight, periovarian adipose mass, and adipocyte diameter, ameliorated lipid accumulation in the liver, and lowered the serum total cholesterol and low-density lipoprotein (LDL-C) levels in HFD-induced female mice. In addition, ACN exhibited a reversal of gut microbial dysbiosis in HFD-fed female mice, such as by enhancing the quantity of Lactobacillus and Allobaculum and reducing the abundance of Blautia and Faecalibaculum. Moreover, the results of fecal BAs showed that ACN led to a decrease in the ratio of primary to secondary BAs, mainly attributed to decreased levels of primary BAs, including CA, CDCA, alpha MCA, and HCA in HFD-induced female mice. Further analysis revealed that ACN may exert its anti-obesity effect by increasing the relative abundance of Lactobacillus_ jonsonii and Lactobacillus_reuteri within the gut and subsequently affecting the metabolism of fecal HDCA and GUDCA. Conclusion: These results indicated that ACN effectively inhibits HFD-induced obesity in female mice by regulating gut microbiota-related BA metabolism.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序