文献类型： 中文期刊
作者： 高鹏 1 ;
作者机构： 1.浙江师范大学化学与生命科学学院
关键词： miRNA;人工miRNA;设计原理
期刊名称： 浙江农业学报
ISSN： 1004-1524
年卷期： 2010 年 22 卷 03 期
页码： 393-397
收录情况： 北大核心 ; CSCD
摘要： miRNA是生物细胞中的一种基因表达负调控因子。人工miRNA是利用天然miRNA生成和作用原理设计的,以一个或多个特定基因为靶标的小RNAs分子,它能够高效、特异地抑制基因的表达。目前人工miRNA技术在调控基因表达、抗病毒领域得到广泛应用。文章综述了天然miRNA的作用原理,amiRNA的优化设计,基因构建及应用技术的最新进展。
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