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Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Wang, Yanhua 1 ; Wang, Qiang 1 ; Ji, Chun 2 ; Guo, Xiaoxuan 3 ; Yang, Guiling 1 ; Wang, Dou 1 ; Weng, Hongbiao 1 ; Qian, 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

2.Tongzhou Dist Comprehens Food Inspect Ctr, Nantong 226300, Jiangsu, Peoples R China

3.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, Minist Agr, Beijing 100081, Peoples R China

4.Shandong Univ, Sch Publ Hlth, Jinan 250012, Shandong, Peoples R China

关键词： Joint toxicity; Aflatoxin B1; Deoxynivalenol; Toxic mechanism; Aquatic vertebrates

期刊名称：ENVIRONMENTAL SCIENCES EUROPE （ 影响因子：5.893； 五年影响因子：6.664 ）

ISSN： 2190-4707

年卷期： 2021 年 33 卷 1 期

页码：

收录情况： SCI

摘要： Background Although humans and animals are often simultaneously exposed to a variety of mycotoxins via feed and food consumption, in which aflatoxin B1 (AFB1) and deoxynivalenol (DON) is one of the most prevalent combination of mycotoxins. Many toxicological studies have merely focused on the impacts of single mycotoxins. In the present study, the combined toxicity and the related mechanism of AFB1 and DON to zebrafish (Danio rerio) were investigated. Results Results exhibited that DON had lower toxicity to embryonic zebrafish with a 7-day LC50 of 218.3 mg a.i. L-1 in comparison to AFB1 (0.031 mg a.i. L-1). The mixture of AFB1 and DON elicited an additive combined effect on zebrafish embryos. The levels of CAT, caspase-3, and T4 markedly varied in most single and mixture groups. The expressions of four genes (cas3, apaf-1, cc-chem, and cyp19a) associated with oxidative stress, cellular apoptosis, immune system, and endocrine system were markedly varied upon the mixture exposure in comparison to the corresponding single exposure of AFB1 or DON. Conclusions Our results revealed that the impacts of a mixture could not be estimated solely based on toxicities of the single mycotoxins. Taken together, our comprehensive investigation on the mycotoxin mixtures and their potential mechanisms could better reflect the reality of mycotoxin contamination in food and feed.

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