Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism
文献类型： 外文期刊
作者： Liu, Huifan 1 ; Zhuang, Shanshan 1 ; Liang, Churong 1 ; He, Junjun 2 ; Brennan, Charles Stephen 3 ; Brennan, Margert Anne 4 ; Ma, Lukai 1 ; Xiao, Gengsheng 1 ; Chen, Hao 6 ; Wan, Shuo 7 ;
作者机构： 1.Zhongkai Univ Agr & Engn, Coll Light Ind & Food, Key Lab Green Proc & Intelligent Mfg Lingnan Spec, Guangzhou 510225, Peoples R China
2.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Haikou, Hainan, Peoples R China
3.RMIT Univ, Sch Sci, Melbourne, Vic, Australia
4.Lincoln Univ, Fac Agr & Life Sci, Dept Wine Food & Mol Biosci, Lincoln, New Zealand
5.Tibet Acad Agr & Anim Husb Sci, Inst Agr Prod Dev & Food Sci, Lhasa 850000, Peoples R China
6.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Peoples R China
7.Jinan Univ, Fac Med Sci, Biomed Translat Res Inst, Guangzhou 510632, Peoples R China
关键词： Amomum villosum Lour. polysaccharide; Structure characterization; Alcohol-induced; Gastric mucosal injure; Mechanism
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）
ISSN： 0144-8617
年卷期： 2022 年 294 卷
页码：
收录情况： SCI
摘要： AVLP-2, a novel acidic polysaccharide, was isolated and purified from Amomum villosum Lour. The structural characteristics of the polysaccharides were characterized using monosaccharide composition, methylation, FT-IR, and NMR techniques. Results showed that AVLP-2 comprises galactose and glucose monomers, has a mo-lecular weight of 10.488 kDa, and has backbone structures -> 4)-alpha-D-GalAp-(1 -> 3,4)-alpha-D-GalAp-(1 ->, -> 4)-alpha-D- GalAp-(1 -> 6)-alpha-D-Galp-(1 ->, and n -> 6)-alpha-D-Galp-(1 -> 4)-alpha-D-Glcp-(1 ->, with alpha-D-Galp-(1 -> branches. Furthermore, AVLP-2 had a significant protective effect against oxidative stress in alcohol-induced injury and LPS inflam-mation models GES-1 cells by regulating the levels of ROS and inflammatory factors. In the animal experiments, AVLP-2 improved the oxidative stress status of the gastric mucosa by increasing SOD activity and GSH levels and inhibiting the excessive generation of malondialdehyde in tissues. The levels of MPO, IL-1 beta, IL-10, and NF-kappa B p65 were downregulated, while that of TNF-alpha was upregulated by AVLP-2 treatment, thereby reducing the alcohol -induced inflammation.
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