您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism

文献类型： 外文期刊

作者： Liu, Huifan 1 ; Zhuang, Shanshan 1 ; Liang, Churong 1 ; He, Junjun 2 ; Brennan, Charles Stephen 3 ; Brennan, Margert Anne 4 ; Ma, Lukai 1 ; Xiao, Gengsheng 1 ; Chen, Hao 6 ; Wan, Shuo 7 ;

作者机构： 1.Zhongkai Univ Agr & Engn, Coll Light Ind & Food, Key Lab Green Proc & Intelligent Mfg Lingnan Spec, Guangzhou 510225, Peoples R China

2.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Haikou, Hainan, Peoples R China

3.RMIT Univ, Sch Sci, Melbourne, Vic, Australia

4.Lincoln Univ, Fac Agr & Life Sci, Dept Wine Food & Mol Biosci, Lincoln, New Zealand

5.Tibet Acad Agr & Anim Husb Sci, Inst Agr Prod Dev & Food Sci, Lhasa 850000, Peoples R China

6.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Peoples R China

7.Jinan Univ, Fac Med Sci, Biomed Translat Res Inst, Guangzhou 510632, Peoples R China

关键词： Amomum villosum Lour. polysaccharide; Structure characterization; Alcohol-induced; Gastric mucosal injure; Mechanism

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）

ISSN： 0144-8617

年卷期： 2022 年 294 卷

页码：

收录情况： SCI

摘要： AVLP-2, a novel acidic polysaccharide, was isolated and purified from Amomum villosum Lour. The structural characteristics of the polysaccharides were characterized using monosaccharide composition, methylation, FT-IR, and NMR techniques. Results showed that AVLP-2 comprises galactose and glucose monomers, has a mo-lecular weight of 10.488 kDa, and has backbone structures -> 4)-alpha-D-GalAp-(1 -> 3,4)-alpha-D-GalAp-(1 ->, -> 4)-alpha-D- GalAp-(1 -> 6)-alpha-D-Galp-(1 ->, and n -> 6)-alpha-D-Galp-(1 -> 4)-alpha-D-Glcp-(1 ->, with alpha-D-Galp-(1 -> branches. Furthermore, AVLP-2 had a significant protective effect against oxidative stress in alcohol-induced injury and LPS inflam-mation models GES-1 cells by regulating the levels of ROS and inflammatory factors. In the animal experiments, AVLP-2 improved the oxidative stress status of the gastric mucosa by increasing SOD activity and GSH levels and inhibiting the excessive generation of malondialdehyde in tissues. The levels of MPO, IL-1 beta, IL-10, and NF-kappa B p65 were downregulated, while that of TNF-alpha was upregulated by AVLP-2 treatment, thereby reducing the alcohol -induced inflammation.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台