Stimuli-responsive biodegradable silica nanoparticles: From native structure designs to biological applications
文献类型： 外文期刊
作者： Qi, Qianhui 1 ; Shen, Qian 2 ; Geng, Jiaying 2 ; An, Weizhen 2 ; Wu, Qiong 2 ; Wang, Nan 6 ; Zhang, Yu 7 ; Li, Xue 7 ; Wang, Wei 1 ; Yu, Changmin 2 ; Li, Lin 8 ;
作者机构： 1.Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310023, Peoples R China
2.Nanjing Tech Univ, Key Lab Flexible Elect KLOFE, Nanjing 211800, Peoples R China
3.Nanjing Tech Univ, Sch Flexible Elect Future Technol, Nanjing 211800, Peoples R China
4.Zhejiang Univ, Innovat Ctr Yangtze River Delta, Future Food Lab, Jiaxing 314100, Peoples R China
5.Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China
6.Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Peoples R China
7.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China
8.Xiamen Univ, Inst Flexible Elect IFE, Future Technol, Xiamen 361005, Peoples R China
关键词： Biodegradation; Silica nanoparticles; Stimuli -responsive; Multiple frameworks; Biological applications
期刊名称：ADVANCES IN COLLOID AND INTERFACE SCIENCE （ 影响因子：15.6； 五年影响因子：14.8 ）
ISSN： 0001-8686
年卷期： 2024 年 324 卷
页码：
收录情况： SCI
摘要： Due to their inherent advantages, silica nanoparticles (SiNPs) have greatly potential applications as bioactive materials in biosensors/biomedicine. However, the long-term and nonspecific accumulation in healthy tissues may give rise to toxicity, thereby impeding their widespread clinical application. Hence, it is imperative and noteworthy to develop biodegradable and clearable SiNPs for biomedical purposes. Recently, the design of multistimuli responsive SiNPs to improve degradation efficiency under specific pathological conditions has increased their clinical trial potential as theranostic nanoplatform. This review comprehensively summaries the rational design and recent progress of biodegradable SiNPs under various internal and external stimuli for rapid in vivo degradation and clearance. In addition, the factors that affect the biodegradation of SiNPs are also discussed. We believe that this systematic review will offer profound stimulus and timely guide for further research in the field of SiNP-based nanosensors/nanomedicine.
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