Structural properties and immunomodulatory activity of an α-glucan purified from the fruiting body of Stropharia rugosoannulata
文献类型： 外文期刊
作者： Zhang, Zuofa 1 ; Song, Tingting 1 ; Lv, Guoying 1 ; Liu, Jie 1 ; Jin, Qunli 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou 310021, Peoples R China
关键词：
Stropharia rugosoannulata; Structural properties; alpha-
期刊名称：CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE （ 影响因子：6.6； 五年影响因子：6.6 ）
ISSN：
年卷期： 2023 年 10 卷 1 期
页码：
收录情况： SCI
摘要： A novel polysaccharide PSRa-2 was purified from Stropharia rugosoannulata fruiting bodies using high pressure homogenization-assisted dual enzyme method, ion exchange, and gel chromatography. The PSRa-2 was characterized via FT-IR, HPAEC, SEM, Congo red test, SEC-MALLS-RI, methylation analysis, and NMR analysis. Structural characterization revealed that PSRa-2 was an alpha-glucan with a Mw 455.6 kDa. The backbone of PSRa-2 was composed of -> 4)-alpha-D-Glcp-(1 -> and -> 3)-alpha-D-Glcp-(1 -> and branches of alpha-D-Glcp-(1 -> at position O-6 of -> 4,6)-alpha-D-Glcp-(1 ->. PSRa-2 induced splenocyte proliferation and protected splenocytes against 5-Fu-induced immunosuppression by restoring the proliferation and secretion of cytokines (TNF-alpha and IL-2) secretion levels. Thus, PSRa-2 exhibits obviously immunomodulatory activity and represents a potential natural immunomodulator.
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