Microbiome-Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of Vanilla planifolia Andrew (EVPA) on Immunosuppressed Mice
文献类型： 外文期刊
作者： Zhang, Xin 1 ; Li, Yunlong 1 ; Zhu, Kexue 1 ; Li, Chuan 2 ; Zhao, Qingyun 1 ; Gu, Fenglin 1 ; Xu, Fei 1 ; Chu, Zhong 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Peoples R China
2.Hainan Univ, Sch Food Sci & Engn, Haikou 570228, Peoples R China
3.Natl Ctr Important Trop Crops Engn & Technol Res, Wanning 571533, Peoples R China
4.Key Lab Proc Suitabil & Qual Control Special Trop, Wanning 571533, Peoples R China
5.Chinese Acad Trop Agr Sci, Sanya Res Inst, Sanya 572000, Peoples R China
关键词： extract of Vanilla planifolia Andrew; metabolomic analysis; immunomodulation; intestinal microbiota
期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）
ISSN：
年卷期： 2024 年 13 卷 5 期
页码：
收录情况： SCI
摘要： This study investigated the immunoprotective effects of the extract of Vanilla planifolia Andrew (EVPA) on cyclophosphamide (Cy)-induced immunosuppression in mice. The results show that EVPA administration significantly alleviated the immune damage induced by Cy, as evidenced by an improved body weight, organ index, and colonic injury. A further analysis of microbial diversity revealed that the EVPA primarily increased the abundance of the beneficial bacteria Verrucomicrobiota, Lactobacillaceae, and Lactobacillus while decreasing Akkermansiaceae, Akkermansia, Romboutsia, and Lactococcus, thereby ameliorating the microbial dysbiosis caused by Cy. A metabolomic analysis revealed significant alterations in the microbial metabolite levels after EVPA treatment, including urobilinogen, formamidopyrimidine nucleoside triphosphate, Cer (d18:1/18:0), pantetheine, and LysoPC (15:0/0:0). These altered metabolites are associated with pathways related to sphingolipid metabolism, carbapenem biosynthesis, pantothenate and CoA biosynthesis, glycerophospholipid metabolism, and porphyrin metabolism. Furthermore, significant correlations were observed between certain microbial groups and the differential metabolites. These findings provide new insights into the immunomodulatory effects of EVPA on the intestinal microbiota and metabolism, laying the foundation for more extensive utilization.
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