Bikaverin as a molecular weapon: enhancing Fusarium oxysporum pathogenicity in bananas via rhizosphere microbiome manipulation
文献类型： 外文期刊
作者： Lu, Honglin 1 ; Guo, Suxia 3 ; Yang, Yongbao 1 ; Zhao, Zhihao 1 ; Xie, Qingbiao 1 ; Wu, Qiong 3 ; Sun, Changjun 3 ; Luo, Hongli 1 ; An, Bang 1 ; Wang, Qiannan 1 ;
作者机构： 1.Hainan Univ, Sanya Inst Breeding & Multiplicat,Natl Key Lab Tro, Sch Breeding & Multiplicat, Sch Trop Agr & Forestry,Sch Agr & Rural Affairs, Sanya, Hainan Province, Peoples R China
2.Hainan Univ, Sch Rural Revitalizat, Sanya, Hainan Province, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Banana Genet Improvement Hainan Prov, Haikou 571101, Hainan Province, Peoples R China
关键词：
Banana wilt disease; Foc TR4; Secondary metabolites; Bikaverin; Rhizosphere microbiome; Plant growth-promoting rhizobacteria;
期刊名称：MICROBIOME （ 影响因子：12.7； 五年影响因子：16.6 ）
ISSN： 2049-2618
年卷期： 2025 年 13 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundFusarium wilt, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4 (Foc TR4), poses a severe threat to global banana production. Secondary metabolites are critical tools employed by pathogens to interact with their environment and modulate host-pathogen dynamics. Bikaverin, a red-colored polyketide pigment produced by several Fusarium species, has been studied for its pharmacological properties, but its ecological roles and impact on pathogenicity remain unclear.ResultsThis study investigated the role of bikaverin in Foc TR4, focusing on its contribution to pathogenicity and its interaction with the rhizosphere microbiome. Pathogenicity assays under sterile and autoclaved conditions demonstrated that bikaverin does not directly contribute to pathogenicity by affecting the infection process or damaging host tissues. Instead, bikaverin indirectly enhances Foc TR4's pathogenicity by reshaping the rhizosphere microbiome. It suppresses beneficial plant growth-promoting rhizobacteria, such as Bacillus, while promoting the dominance of fungal genera, thereby creating a microbial environment beneficial for pathogen colonization and infection. Notably, bikaverin biosynthesis was found to be tightly regulated by environmental cues, including acidic pH, nitrogen scarcity, and microbial competition. Co-culture with microbes such as Bacillus velezensis and Botrytis cinerea strongly induced bikaverin production and upregulated expression of the key bikaverin biosynthetic gene FocBik1. In addition, the identification of bikaverin-resistant Bacillus BR160, a strain with broad-spectrum antifungal activity, highlights its potential as a biocontrol agent for banana wilt management, although its stability and efficiency under field conditions require further validation.ConclusionsBikaverin plays an indirect yet important role in the pathogenicity of Foc TR4 by manipulating the rhizosphere microbiome. This ecological function underscores its potential as a target for sustainable disease management strategies. Future research should focus on elucidating the molecular mechanisms underlying bikaverin-mediated microbial interactions, using integrated approaches such as transcriptomics and metabolomics. Together, these findings provide a foundation for novel approaches to combat banana wilt disease and enhance crop resistance.5a5ByL_1dDSoawfkb5-5kxVideo AbstractConclusionsBikaverin plays an indirect yet important role in the pathogenicity of Foc TR4 by manipulating the rhizosphere microbiome. This ecological function underscores its potential as a target for sustainable disease management strategies. Future research should focus on elucidating the molecular mechanisms underlying bikaverin-mediated microbial interactions, using integrated approaches such as transcriptomics and metabolomics. Together, these findings provide a foundation for novel approaches to combat banana wilt disease and enhance crop resistance.5a5ByL_1dDSoawfkb5-5kxVideo Abstract
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