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Polygonatum kingianum Polysaccharides Enhance the Preventive Efficacy of Heat-Inactivated Limosilactobacillus reuteri WX-94 against High-Fat-High-Sucrose-Induced Liver Injury and Gut Dysbacteriosis

文献类型： 外文期刊

作者： Liu, Tianqi 1 ; Zhou, Lanqi 1 ; Li, Xiaoqiong 5 ; Song, Wei 1 ; Liu, Yuan 2 ; Wu, Shan 3 ; Wang, Peng 1 ; Dai, Xiaoshuang 4 ; Shi, Lin 1 ;

作者机构： 1.Shaanxi Normal Univ, Sch Food Engn & Nutr Sci, Xian 710119, Peoples R China

2.Shaanxi Normal Univ, Sch Phys Educ, Xian 710119, Peoples R China

3.Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China

4.BGI Inst Appl Agr, BGI Agro, Shenzhen 518083, Guangdong, Peoples R China

5.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

关键词： Polygonatum kingianum polysaccharides; Limosilactobacillus reuteri; liver injury; fatty acid metabolism; gut microbiota

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 17 期

页码：

收录情况： SCI

摘要： Limosilactobacillus reuteri (L. reuteri) is an efficacious probiotic that could reduce inflammation and prevent metabolic disorders. Here, we innovatively found that Polygonatum kingianum polysaccharides (PKP) promoted proliferation and increased stability of L. reuteri WX-94 (a probiotic strain showing anti-inflammation potentials) in simulated digestive fluids in vitro. PKP was composed of galactose, glucose, mannose, and arabinose. The cell-free supernatant extracted from L. reuteri cultured with PKP increased ABTS center dot+, DPPH center dot, and FRAP scavenging capacities compared with the supernatant of the medium without PKP and increased metabolites with health-promoting activities, e.g., 3-phenyllactic acid, indole-3-lactic acid, indole-3-carbinol, and propionic acid. Moreover, PKP enhanced alleviating effects of heat-inactivated L. reuteri on high-fat-high-sucrose-induced liver injury in rats via reducing inflammation and regulating expressions of protein and genes involved in fatty acid metabolism (such as HIF1-alpha, FA beta O, CPT1, and AMPK) and fatty acid profiles in liver. Such benefits correlated with its prominent effects on enriching Lactobacillus and short-chain fatty acids while reducing Dubosiella, Fusicatenilacter, Helicobacter, and Oscillospira. Our work provides novel insights into the probiotic property of PKP and emphasizes the great potential of the inactivated L. reuteri cultured with PKP in contracting unhealthy diet-induced liver dysfunctions and gut dysbacteriosis.

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