Metagenomics reveals rare and abundant resistome had different resistance and transmission risk in park environment
文献类型： 外文期刊
作者： Bi, Jie 1 ; Gan, Xueying 1 ; Shi, Chenwei 1 ; Han, Qian 1 ; Wang, Xiaochen 1 ; Yu, Qiaoling 2 ; Xie, Zhigang 3 ; Li, Huan 1 ;
作者机构： 1.Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, Ctr Grassland Microbiome, State Key Lab Grassland Agroecosystems, Lanzhou 730000, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Hydrobiol, Hangzhou 310021, Peoples R China
关键词： Antibiotic resistance genes; Urban parks; Risk assessment; Driving factors; Metagenomics
期刊名称：ENVIRONMENTAL TECHNOLOGY & INNOVATION （ 影响因子：7.1； 五年影响因子：7.1 ）
ISSN： 2352-1864
年卷期： 2025 年 38 卷
页码：
收录情况： SCI
摘要： Urban parks are essential to human life and provide a potential pathway for the spread of antibiotic resistance genes (ARGs) from the environment to humans. However, there are few studies to investigate the risk of ARGs in urban parks, particularly ARGs with different distributions. In this study, we used metagenomics, 16S rRNA gene sequencing and physiochemical properties testing to investigate the profiles of abundant and rare ARGs with different distributions from soil and water in nine urban parks, and then assessed their risk and colonization in the human gut by comparing them with the intestinal resistome of local residents. The results showed that abundant ARGs had higher potential transmission risk, but rare ARGs posed stronger resistance risk, host pathogenic risk and were more likely to colonize the human gut. Notably, rare ARGs contained more high-risk ARGs that may colonize humans. Network analysis showed rare ARGs in water maintain stability of ARGs co-occurrence network. Abundant ARGs were mainly dominated by nutritional factors (e.g., TS), whereas rare ARGs were mainly driven by bacterial community diversity. This study revealed that ARGs in urban parks pose different ecological risk to humans and provided a theoretical basis for public health and environmental management in urban parks.
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