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A Versatile Nanoplatform Based on Metal-Phenolic Networks Inhibiting Tumor Growth and Metastasis by Combined Starvation/Chemodynamic/Immunotherapy

文献类型： 外文期刊

作者： Fu, Zhaoming 1 ; Zhang, Yufei 1 ; Chen, Xiaolu 2 ; Wang, Nan 1 ; Ma, Rongying 1 ; Luo, Xingyu 1 ; Pan, Xin 1 ; Yang, Yong 1 ; Xue, Wei 3 ;

作者机构： 1.Hainan Univ, Sch Food Sci & Engn, Key Lab Food Nutr & Funct Food Hainan Prov, R China, Haikou 570228, Peoples R China

2.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Haikou 570100, Peoples R China

3.Jinan Univ, Key Lab Biomat Guangdong Higher Educ Inst, Guangdong Prov Engn & Technol Res Ctr Drug Carrier, Dept Biomed Engn, Guangzhou 510632, Peoples R China

关键词： chemodynamic therapy; glucose oxidase; immune responses; metal-phenolic networks; TAMs polarization

期刊名称：ADVANCED FUNCTIONAL MATERIALS （ 影响因子：19.0； 五年影响因子：19.2 ）

ISSN： 1616-301X

年卷期： 2023 年 33 卷 7 期

页码：

收录情况： SCI

摘要： Although much progress has been made by multifunctional nanoplatforms in the treatment of cancer, several defects of existing nanoplatforms, such as tedious preparation, poor biocompatibility, and failure to activate the immune system, have limited their clinical applications. Herein, a versatile nanosystem of folic acid-modified metal-phenolic networks (MPNs) loaded with GOx and CHA (F-MGC) is fabricated by the easy self-assembly of MPNs, during which glucose oxidase (GOx) and chlorogenic acid (CHA) are concurrently loaded. The resulting nanosystem, having a folic acid-modified surface and inherent acid sensitivity, shows versatility in being able to target tumors and release active ingredients in the weakly acidic tumor microenvironment (TME). Based on the catalysis of GOx and Fe3+, the cascade reaction aroused by F-MGC efficiently consumes glucose in the TME and produces abundant cytotoxic hydroxyl radicals, thereby causing the starving and chemodynamic death of cancer cells. In addition, CHA can reshape M2 tumor-associated macrophages (TAMs) into the M1 type, so as to change the immunosuppressive state of TME. The immunogenic cell death (ICD) that occurs from the starvation and chemodynamic therapy, in conjunction with the CHA-induced TAMs polarization, further activates the immune system. Overall, the easily prepared nanoplatform has excellent biocompatibility and effectively inhibits tumor growth and metastasis.

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