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Effects of mixed extract from two tropical plants on gut microbiome and metabolome in piglets

文献类型： 外文期刊

作者： Zhou, Luli 1 ; Hou, Guanyu 1 ; Liu, Shengmin 2 ; Zhou, Hanlin 3 ; Ye, Yuxiu 4 ; Lv, Renlong 1 ; Abouelezz, Khaled 1 ; Wang, Dingfa 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Haikou 571101, Peoples R China

2.Hainan State Farm Bur Husb Grp, Haikou, Peoples R China

3.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang, Peoples R China

4.Hainan Yitian Biotechnol, Haikou, Peoples R China

5.Assiut Univ, Fac Agr, Dept Poultry Prod, Assiut, Egypt

关键词： extract mixture; guava leaf extract; gut microbiome; metabolome; Piper sarmentosum extract

期刊名称：JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION （ 影响因子：2.7； 五年影响因子：2.6 ）

ISSN： 0931-2439

年卷期： 2024 年

页码：

收录情况： SCI

摘要： In this study, we performed a quantitative analysis of 12 compounds derived from Piper sarmentosum extract (PSE) and guava leaf extract (GE). In addition, we investigated the effects of mixed extract (ME) of PSE and GE (1:1) on piglets' gut microbiome and metabolome. A total of 200 piglets (Duroc x Landrace x Large Yorkshire, 21-day-old) were randomly assigned into two groups with five replicates of 20 piglets/pen having the same initial body weight. Piglets were fed a basal diet supplemented with ME at 0 (T0) or 200 mg/kg (T1) for 3 weeks. The quantitation results by ultraperformance liquid chromatography linked to triple-quadrupole tandem mass spectrometry showed that vitexin 2-O-rhamnoside and pellitorine were the greatest abundant among six compounds detected in the PSE. In addition, quercetin, isoquercitrin and avicularin were found to be the richest of all detected compounds in the GE. Findings on experimental animals indicated that three differential metabolites, comprising L-alanine, sarcosine and dihydrofolic acid, in T1 compared with T0 groups, have exactly opposite levels trends in serum and faeces. Moreover, two metabolic pathways (i.e., urea cycle and glutamate metabolism) differed significantly in the serum and faeces of piglets between T0 and T1 (p < 0.05). At the same time, T1 had significantly higher relative abundances of Agathobacter and Alloprevotella than T0 at genus level (p < 0.05). Correlation analysis revealed that the genus Agathobacter correlated positively with carbamoyl phosphate (p < 0.01) and oxoglutaric acid (p < 0.05), and negatively with succinic acid (p < 0.01) and ornithine (p < 0.05). These four differential metabolites were also involved in the urea cycle and/or glutamate metabolism pathways. The results here indicated that the tested plant extract mixture represents a worthy feed additive with obvious antioxidative properties.

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