Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS
文献类型： 外文期刊
作者： Yao, Zhenzhen 1 ; Li, Bingru 1 ; Li, Cheng 1 ; Wang, Beihong 1 ; Zhao, Meng 1 ; Ma, Zhihong 1 ;
作者机构： 1.BAAFS Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China
期刊名称：JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY （ 影响因子：4.351； 五年影响因子：4.059 ）
ISSN： 0267-9477
年卷期： 2022 年 37 卷 8 期
页码：
收录情况： SCI
摘要： This work establishes a hyphenated methodology coupling HPLC with ICP-MS for the determination of platinum chloride complexes as synthetic impurities of platinum-based drugs for the first time. The separation of inorganic platinum-chloride complexes was accomplished in less than 3 min on an anion exchange column with a mobile phase containing 2 mmol L-1 (v : v) HCl. The detection limits were found to be 0.2 mu g L-1 and 0.3 mu g L-1 for potassium hexachloroplatinate (K2PtCl6) and potassium chloroplatinate (K2PtCl4), respectively. Method precision and accuracy were satisfactory at <3% relative standard deviations (RSDs) for 10 mu g L-1 of K2PtCl6 and K2PtCl4, and >90% recoveries for real samples. The method has the advantages of simplicity, rapidity and sensitivity, and provides a basis for quality control of trace impurities in the production process of platinum-based drugs.
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