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Antifungal activity and metabolomics analysis of Piper sarmentosum extracts against Fusarium graminearum

文献类型： 外文期刊

作者： Zhou, Luli 1 ; Zhou, Hanlin 1 ; Hou, Guanyu 1 ; Ji, Fengjie 1 ; Wang, Dingfa 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, 4 Xueyuan Rd, Haikou 571101, Peoples R China

2.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China

关键词： Fusarium graminearum; Piper sarmentosum extract; antifungal activity; antifungal compounds; metabolomics; natural anti-mildew agent

期刊名称：JOURNAL OF APPLIED MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：4.3 ）

ISSN： 1364-5072

年卷期： 2023 年 134 卷 3 期

页码：

收录情况： SCI

摘要： Aims Fusarium graminearum is a toxic fungus that affects food and feed crops. Piper sarmentosum extract (PSE) is a potential source of anti-mildew natural products for the food and feed industry due to its various pharmacological properties. In this study, we evaluated the antifungal activity and untargeted metabolomics analysis of PSE against F. graminearum. Methods and results Antifungal activity was evaluated using the mycelium growth rate method. Untargeted metabolomics analysis of PSE was performed using ultra high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The results showed that PSE (1 and 2 mg ml(-1)) possesses inhibitory activity against F. graminearum, and a total of 17 compounds that including 8 alkaloids, 3 phenols, 3 lipids, and 3 organic acids might be the antifungal markers in PSE. Metabolomics analysis further revealed that PSE could significantly increase the levels of guanosine, guanine, adenosine, and L-isoleucine in fungi, which are related to purine and L-isoleucine metabolic pathways. Conclusions PSE is a promising anti-mildew agent that inhibits the growth of F. graminearum in food and feed. PSE (1 and 2 mg ml(-1)) may exert antifungal properties by inhibiting fungal purine nucleotide synthesis and enhancing the level of L-isoleucine compared with the control groups.

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