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Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (Oryzias sinensis): A Study from Laboratory to Field

文献类型： 外文期刊

作者： Fan, Xiaolin 1 ; Guo, Jilong 1 ; Jia, Xiaojing 1 ; Mao, Xingtai 1 ; Zhou, Ying 1 ; Wang, Yue 1 ; Guo, Xuan 1 ; Shen, Jiashu 1 ; Huai, Narma 1 ; Zhang, Kailun 1 ; Abdusalam, Abida 1 ; Hu, Hongxia 2 ; Zhu, Hua 2 ; Jia, Chengxia 2 ; Cheng, Lan 1 ; Li, Xiqing 1 ; Zhang, Zhaobin 1 ;

作者机构： 1.Peking Univ, Coll Urban & Environm Sci, MOE Lab Earth Surface Proc, Beijing 100871, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Fisheries Res Inst, Beijing 100068, Peoples R China

关键词： fluorene-9-bisphenol; Chinese medaka; antiestrogenicity; reproductive toxicity; teratogenicity; eye malformations

期刊名称：ENVIRONMENTAL SCIENCE & TECHNOLOGY （ 影响因子：11.357； 五年影响因子：12.154 ）

ISSN： 0013-936X

年卷期：

页码：

收录情况： SCI

摘要： Fluorene-9-bisphenol (BHPF), a bisphenol A (BPA) substitute, has been increasingly used as a material in syntheses of polymers that are widely used in road markings, artificial tracks, coating floors, building paints, etc., increasing the likelihood of BHPF contamination in the aquatic environment due to its release from the products. However, to date, it is unknown whether it may have actual impacts on fish in real environments. In this study, a 105-day exposure experiment of BHPF at various concentrations (0.01, 0.1, 1, and 10 mu g/ L) on Chinese medaka (Oryzias sinensis) was performed under laboratory conditions and found decreased fecundity, such as lower egg qualities and quantities, retarded oogenesis, and atretic follicles in the fish and deformed eyes and bodies in its F1 generation. Toxicotranscriptome analyses showed that estrogen-responsive genes were significantly suppressed by BHPF, indicating that antagonist properties of BHPF on estrogen receptors might be causes for the decreased fecundity. Field investigations (Beijing) demonstrated that BHPF was detectable in 60% surface waters, with a mean concentration of 10.49 +/- 6.33 ng/L, by gas chromatography-mass spectrometry, and similar effects in wild Chinese medaka were also observed, some of which the parameters were found to be obviously correlated with the BHPF levels in corresponding waters.

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