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Pharmacokinetics and residue elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss)

文献类型： 外文期刊

作者： Wang, Zhuoqun 1 ; Yang, Yan 1 ; Mu, Yingchun 2 ; Liu, Bo 1 ; Zhang, Pei 1 ; Zhang, Xin 4 ; Sun, Huiwu 2 ; Song, Yi 2 ; Cheng, Bo 2 ;

作者机构： 1.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China

2.Chinese Acad Fishery Sci, Qual & Stand Res Ctr, Qingta West Rd 150, Beijing 100141, Peoples R China

3.Minist Agr, Key Lab Aquat Prod Qual & Safety Control, Beijing, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Beijing Fisheries Res Inst, Beijing, Peoples R China

关键词： elimination; norfloxacin; pharmacokinetics; rainbow trout; residues

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.567； 五年影响因子：1.657 ）

ISSN： 0140-7783

年卷期： 2022 年 45 卷 3 期

页码：

收录情况： SCI

摘要： We studied the metabolism and elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss) following a single oral administration of 50 mg/kg at 15 +/- 2 degrees C. Norfloxacin was measured by high-performance liquid chromatography-tandem mass spectrometry in plasma, muscle, liver, kidney, skin and remainder tissues, and the concentrationtime curve was characterized by a double peak. The drug was absorbed rapidly; the first peak appeared within 4 h, and the second peak appeared within 24 h in all substrates tested. The maximal concentrations in plasma, muscle, liver and kidney were 0.468 mg/L, 14.146 mg/kg, 6.445 mg/kg and 0.977 mg/kg, respectively. The distribution half-life was 5.814, 9.026, 17.027 and 1.004 h, respectively. The elimination half-life was 41.205, 41.667, 44.896 and 54.908 h, respectively. Using the kidney as the reference tissue for norfloxacin monitoring in aquaculture and 2 mu g/kg as a maximum residue limit standard, it takes 555 temperature-day (degrees C days) for norfloxacin to be completely eliminated from rainbow trout.

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