Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii
文献类型： 外文期刊
作者： Sun, Yuqing 1 ; Huo, Jinxi 1 ; Zhong, Shi 1 ; Zhu, Jianxun 1 ; Li, Yougui 1 ; Li, Xiaojun 2 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, 198 Shiqiao Rd, Hangzhou 310021, Peoples R China
2.Yangzhou Borui Saccharide Biotech Co Ltd, Yangzhou 225000, Jiangsu, Peoples R China
关键词： Phellinus baumii; Polysaccharide; Structure; Anti-inflammatory activity; Inflammatory bowel disease
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）
ISSN： 0144-8617
年卷期： 2021 年 268 卷
页码：
收录情况： SCI
摘要： Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. SHPS-1 consisted of arabinose, mannose, glucose, and galactose at a molar ratio of 2.2:15.7:49.3:32.8. SHPS-1 had a backbone containing 1,3linked 8-D-Glcp and 1,6-linked alpha-D-Galp residues, and Araf, Manp and Galp units were attached as oligosaccharidic side chains to the backbone at C-6 of some glucopyranoses. SHPS-1 decreased phosphorylation level of STAT-1 and expression levels of STAT-1 targeted genes such as iNOS and TNF-alpha in lipopolysaccharidestimulated macrophage RAW 264.7 cells. Furthermore, SHPS-1 promoted the expression of IL-10 and macrophage mannose receptor CD 206, markers of tissue repairing macrophages. SHPS-1 alleviated ulcerative colitis in mice by decreasing pro-inflammatory genes and increasing anti-inflammatory and tissue repairing genes. Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD.
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