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Probiotic Potential of Enterococcus lactis GL3 Strain Isolated from Honeybee (Apis mellifera L.) Larvae: Insights into Its Antimicrobial Activity Against Paenibacillus larvae

文献类型： 外文期刊

作者： Ye, Manhong 1 ; Jiang, Yinhong 1 ; Han, Qiannan 1 ; Li, Xiaoyuan 1 ; Meng, Chuang 2 ; Ji, Chao 3 ; Ji, Feng 4 ; Zhou, Bin 5 ;

作者机构： 1.Yangzhou Univ, Coll Biosci & Biotechnol, Yangzhou 225009, Peoples R China

2.Yangzhou Univ, Jiangsu Key Lab Zoonosis, Yangzhou 225009, Peoples R China

3.Fubiao Biotech Co Ltd, Huaian 211799, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100089, Peoples R China

5.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China

关键词： honeybee larvae; lactic acid bacteria; Paenibacillus larvae; Enterococcus lactis; aborycin

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

ISSN：

年卷期： 2025 年 12 卷 2 期

页码：

收录情况： SCI

摘要： This study aimed to address the need for effective probiotics and antibacterial agents to combat American foulbrood disease in honeybees, caused by Paenibacillus larvae. In the context of declining honeybee populations due to pathogens, we isolated eight lactic acid bacteria (LAB) strains from honeybee larvae (Apis mellifera L.) and evaluated their probiotic potential and inhibitory effects against P. larvae. Methods included probiotic property assessments, such as acid and bile salt resistance, hydrophobicity, auto-aggregation, co-aggregation with P. larvae, antioxidant capacities, osmotolerance to 50% sucrose, and antibiotic susceptibility. Results indicated that the GL3 strain exhibited superior probiotic attributes and potent inhibitory effects on P. larvae. Whole-genome sequencing revealed GL3 to be an Enterococcus lactis strain with genetic features tailored to the honeybee larval gut environment. Pangenome analysis highlighted genetic diversity among E. lactis strains, while molecular docking analysis identified aborycin, a lasso peptide produced by GL3, as a promising inhibitor of bacterial cell wall synthesis. These findings suggested that GL3 was a promising probiotic candidate and antibacterial agent for honeybee health management, warranting further investigation into its in vivo efficacy and potential applications in beekeeping practices.

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