文献类型： 外文期刊

作者： Bi, Yuhai ¹ ; Li, Juan ⁴ ; Li, Shanqin ² ; Fu, Guanghua ⁵ ; Jin, Tao ⁶ ; Zhang, Cheng ¹ ; Yang, Yongchun ⁸ ; Ma, Zhenghai ⁷ ;

作者机构： 1.Chinese Acad Sci, CAST WAS Ctr Excellence Emerging Infect Dis CEEID, Ctr Influenza Res & Earlywarning CASCIRE, Inst Microbiol,CAS Key Lab Pathogen Microbiol & I, Beijing 100101, Peoples R China

2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China

3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Guangdong Key Lab Diag & Treatment Emergin, Shenzhen Key Lab Pathogen & Immun,State Key Disci, Shenzhen 518112, Peoples R China

4.Shandong First Med Univ & Shandong Acad Med Sci, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An 271016, Shandong, Peoples R China

5.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China

6.BGI Shenzhen, China Natl Genebank Shenzhen, Shenzhen 518083, Peoples R China

7.Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China

8.Zhejiang A&F Univ, Coll Anim Sci & Technol, Zhejiang Prov Engn Lab Anim Hlth Inspect & Intern, Hangzhou 311300, Peoples R China

9.Zhejiang A&F Univ, Coll Vet Med, Hangzhou 311300, Peoples R China

10.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China

11.Zunyi Med Univ, Coll Publ Hyg, Inst Zoonosis, Zunyi 563003, Guizhou, Peoples R China

12.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

13.Jilin Univ, Coll Vet Med, Dept Vet Prevent Med, Jilin 130062, Jilin, Peoples R China

14.Hainan Med Univ, Sch Basic Med & Life Sci, Haikou 571101, Hainan, Peoples R China

15.Diqing Tibetan Autonomous Prefecture Ctr Dis Cont, Shangri La 674400, Peoples R China

16.Chinese Acad Sci, CASCIRE, Ctr Biosafety Mega Sci, Wuhan Inst Virol,CAS Key Lab Special Pathogens &, Wuhan 430071, Peoples R China

17.Henan Inst Sci & Technol, Coll Anim Sci & Technol, Xinxiang 453003, Henan, Peoples R China

18.Southwest Univ, Coll Anim Sci, Chongqing 402460, Peoples R China

19.Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai 200031, Peoples R China

20.Univ Laval, Dept Microbiol Infectiol & Immunol, Quebec City, PQ G1V 0A6, Canada

21.Novosibirsk State Univ, Russian Acad Sci, Fed Res Ctr Fundamental & Translat Med, Fed State Budget Sci Inst,Siberian Branch, Novosibirsk 630090, Russia

22.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

23.State Forestry & Grassland Adm, Gen Stn Surveillance Wildlife Borne Infect Dis, Shenyang 110034, Liaoning, Peoples R China

24.Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Tai An 271000, Shandong, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2020 年 11 卷 1 期

页码：

收录情况： SCI

摘要： We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014-2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide. In this study, the authors present a genomic surveillance of avian influenza genomes sampled from live poultry markets in China. They report that a number of variants have emerged since 2016 that pose an increased risk to humans. They highlight the importance of continuous genome surveillance of circulating influenza strains.