文献类型： 外文期刊

作者： Dong, Miaoyin ¹ ; Li, Jinjuan ³ ; Yang, Delong ¹ ; Li, Mengfei ² ; Wei, Jianhe ⁵ ;

作者机构： 1.Gansu Agr Univ, Coll Life Sci & Technol, Lanzhou 730070, Peoples R China

2.Gansu Agr Univ, State Key Lab Arid Land Crop Sci, Lanzhou 730070, Peoples R China

3.Gansu Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Lanzhou 730070, Peoples R China

4.Gansu Agr Univ, Agron Coll, Lanzhou 730070, Peoples R China

5.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

关键词： Astragalus membranaceus; flavonoids; triterpene saponins; polysaccharides; biosynthesis; pharmacological activity

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2023 年 28 卷 13 期

页码：

收录情况： SCI

摘要： Astragalus membranaceus (A. membranaceus), a well-known traditional herbal medicine, has been widely used in ailments for more than 2000 years. The main bioactive compounds including flavonoids, triterpene saponins and polysaccharides obtained from A. membranaceus have shown a wide range of biological activities and pharmacological effects. These bioactive compounds have a significant role in protecting the liver, immunomodulation, anticancer, antidiabetic, antiviral, antiinflammatory, antioxidant and anti-cardiovascular activities. The flavonoids are initially synthesized through the phenylpropanoid pathway, followed by catalysis with corresponding enzymes, while the triterpenoid saponins, especially astragalosides, are synthesized through the universal upstream pathways of mevalonate (MVA) and methylerythritol phosphate (MEP), and the downstream pathway of triterpenoid skeleton formation and modification. Moreover, the Astragalus polysaccharide (APS) possesses multiple pharmacological activities. In this review, we comprehensively discussed the biosynthesis pathway of flavonoids and triterpenoid saponins, and the structural features of polysaccharides in A. membranaceus. We further systematically summarized the pharmacological effects of bioactive ingredients in A. membranaceus, which laid the foundation for the development of clinical candidate agents. Finally, we proposed potential strategies of heterologous biosynthesis to improve the industrialized production and sustainable supply of natural products with pharmacological activities from A. membranaceus, thereby providing an important guide for their future development trend.