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First report of the multiresistance gene cfr in Pasteurella multocida strains of avian origin from China

文献类型： 外文期刊

作者： Chen, Hongmei 1 ; Deng, Hui 2 ; Cheng, Longfei 3 ; Liu, Rongchang 3 ; Fu, Guanghua 3 ; Shi, Shaohua 3 ; Wan, Chunhe 3 ; F 1 ;

作者机构： 1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350013, Peoples R China

2.Fujian Agr & Forestry Univ, Coll Anim Sci, Fujian Prov Key Lab Tradit Chinese Vet Med & Anim, Coll Bee Sci, Fuzhou 350002, Peoples R China

3.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fujian Anim Dis Control Technol Ctr, Fujian Prov Key Lab Avian Dis Control & Prevent, Fuzhou 350013, Peoples R China

4.Fujian Agr & Forestry Univ, Coll Anim Sci, Coll Bee Sci, Fuzhou 350002, Peoples R China

5.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China

关键词： Pasteurella multocida; cfr; Resistance gene; Florfenicol; ISApl1; IS256

期刊名称：JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE （ 影响因子：4.035； 五年影响因子：3.611 ）

ISSN： 2213-7165

年卷期： 2020 年 23 卷

页码：

收录情况： SCI

摘要： Objectives: The aim of this study was to investigate the presence and genetic environment of the multiresistance gene cfr gene in Pasteurella multocida of avian origin from China. Methods: A total of 113 P. multocida isolates were collected from sick poultries (ducks, chickens and geese) from 2003 to 2016 in Southern China and were screened for the presence of the cfr gene by PCR. The cfr-carrying P. multocida strains were subjected to antimicrobial susceptibility testing, 51 nuclease PFGE and Southern blot hybridisation, conjugative transfer and analysis of genetic environment of the cfr gene. Results: Among 113 P. multocida isolates, strains F16671 and F16683 from Muscovy duck harboured the cfr gene and presented a multiresistant phenotype. The cfr gene in the two strains was located on an similar to 40-kb conjugative plasmid in different genetic environments, including ISApl1(2)-cfr-IS26 and IS26-cfr-IS256. Conclusions: These results demonstrate plasmid-carried cfr in P. multocida and suggest that transposition and homologous recombination mediated by IS26, ISApl1 and IS256 might have played an important role in transfer of the cfr gene in P. multocida. To the best of our knowledge, this is the first report of the cfr gene in P. multocida. Active and ongoing surveillance of cfr in P. multocida is urgently warranted. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.

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