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Development of a Pass-through SPE Cartridge for the Rapid Determination of Fipronil and Its Metabolites in Chicken Eggs by LC-MS/MS

文献类型： 外文期刊

作者： Zhang, Qiaoyan 1 ; Wang, Xiajun 2 ; Wang, Xuming 2 ; Guo, Hui 3 ; Chen, Guanghui 2 ; Shan, Ying 1 ; Fang, Weihuan 1 ;

作者机构： 1.Zhejiang Univ, Coll Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

关键词： Fipronil; Pigment; Lipid; Protein; Cleanup; LC-MS; MS

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.366； 五年影响因子：3.07 ）

ISSN： 1936-9751

年卷期： 2021 年 14 卷 5 期

页码：

收录情况： SCI

摘要： In this work, a novel pass-through cleanup cartridge was developed for the rapid determination of fipronil and its metabolites in chicken eggs by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The systemic elimination experiments on pigments, lipids, proteins, and so on were performed, and then a multi-function SPE cartridge containing three sorbents (PestiCarb, Alumina-N, and COOH) was designed. Using this cartridge, a simple cleanup procedure with the ideal elimination effects was achieved by gravity in less than 1 min. The involved LC-MS/MS method provided satisfactory performance. The tested recoveries were in the range of 78.6-87.1% with the relative standard deviations (RSDs) less than 8.3%. The limits of quantitation (LOQs) of fipronil, fipronil-desulfinyl, fipronil-sulfone, and fipronil-sulfide were 1, 0.5, 1, and 0.5 mu g/kg, respectively. This method was successfully applied to detect some chicken eggs from local markets and farms. A positive sample of 5.3 mu g/kg fipronil and 31.8 mu g/kg fipronil-sulfone was found and the potential risk root was traced. In the future, a specific device equipped with a lot of the above-developed cartridges could be designed for the rapid and high-throughput cleanup. It would be helpful to reduce the manual labor and save the time of sample pretreatment.

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