Combined endocrine disruptive toxicity of malathion and cypermethrin to gene transcription and hormones of the HPG axis of male zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Guo, Dongmei 1 ; Liu, Wenping 3 ; Yao, Tingshan 4 ; Ma, Mengmeng 2 ; Wang, Qiang 1 ; Qiu, Jing 2 ; Qian, Yongzhong 2 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Zhejiang, Peoples R China
2.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Minist Agr, Key Lab Agroprod Qual & Safety, Beijing 100081, Peoples R China
3.Jilin Acad Agr Sci, Crop Germplasm Resources Inst, Changchun 136100, Peoples R China
4.Southwest Univ, Citrus Res Inst, Chongqing 400712, Peoples R China
关键词： Cypermethrin; Malathion; Adult zebrafish; Combined effect; Hypothalamic-pituitary-gonadal
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2021 年 267 卷
页码：
收录情况： SCI
摘要： Cypermethrin (CYP) and malathion (MAT) have been widely used and are frequently detected in surface waters. The purpose of the present study was to investigate the endocrine disrupting toxicity of CYP, MAT, and CYP + MAT to 5-month-old male zebrafish (Danio rerio). After exposure, the hepatosomatic index (HSI) and gonadosomatic index (GSI) did not change significantly. Following exposure to the combination of 0.1 mu g/L CYP +25 mu g/L MAT, the E2 and VTG levels of male zebrafish were significantly increased compared to those after individual pesticide treatments. The molecular level of the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish was studied; it was found that the expression of the estrogen-related genes, especially the vtgl gene, was significantly altered in 0.1 mu g/L CYP + 25 mu g/L MAT. Overall, our observation indicated that CYP or MAT could disturb the hormonal balance, and their combination of 0.1 mu g/L CYP +25 mu g/L MAT could significantly enhance the estrogenic effect. (C) 2020 Elsevier Ltd. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Tuning the Dynamic Reaction Balance of CRISPR/Cas12a and RPA in One Pot: A Key to Switch Nucleic Acid Quantification
作者：Yao, Zhihao;Wu, Qun;Yao, Zhihao;Xu, Yan;Wu, Qun;Yao, Zhihao;Xu, Yan;Wu, Qun;Yao, Zhihao;He, Kaiyu;Wang, Hongmei;Wang, Qiang;Xu, Xiahong;Wang, Liu;Yao, Zhihao;He, Kaiyu;Wang, Hongmei;Wang, Qiang;Xu, Xiahong;Wang, Liu;Feng, Suyin;Ding, Xiaoqing;Wang, Liu
关键词：quantification; CRISPR/Cas12a; isothermal amplification; nucleic acid; one pot
-
Carbendazim residue in plant-based foods in China: Consecutive surveys from 2011 to 2020
作者：Wang, Dou;Yang, Guiling;Luo, Ting;Guo, Hao;Pan, Liying;Wang, Yanhua;Wang, Qiang;Yun, Xiao;Du, Wei;Wang, Pu;Zhang, Qinghua;Li, Yun;Lin, Nan;Li, Yun
关键词：Carbendazim; Plant-based foods; China; Spatial-temporal variations; Exposure and risk assessment
-
Long-term biogas slurry application increases microbial necromass but not plant lignin contribution to soil organic carbon in paddy soils as regulated by fungal community
作者：Chen, Zhaoming;Ma, Jinchuan;Ma, Junwei;Ye, Jing;Yu, Qiaogang;Zou, Ping;Sun, Wanchun;Lin, Hui;Wang, Feng;Wang, Qiang;Zhao, Xinlin
关键词：Soil organic carbon; Lignin phenols; Microbial necromass; Microbial community structure; Biogas slurry
-
Long-term successive biochar application increases plant lignin and microbial necromass accumulation but decreases their contributions to soil organic carbon in rice-wheat cropping system
作者：Chen, Zhaoming;He, Lili;Ma, Jinchuan;Ma, Junwei;Ye, Jing;Yu, Qiaogang;Zou, Ping;Sun, Wanchun;Lin, Hui;Wang, Feng;Wang, Qiang;Zhao, Xu
关键词：amino sugars; biochar; lignin phenols; microbial necromass; paddy field; soil organic carbon
-
Contents of flavonoid compounds in Dendrobium officinale Kimura et Migo determined by QuEChERS-HPLC-MS/MS: Method validation and influencing factors
作者：Sun, Fengting;Xu, Zhenlan;Zhu, Zuoyi;Zhang, Chunrong;Tang, Tao;Wang, Qiang;Zhao, Xueping;Sun, Fengting;Sheng, Qing;Xu, Xiaoyan;Gao, Yan;Han, Xinyu
关键词：QuEChERS; Flavonoid components; The origin; Cultivation method; Dendrobium officinale Kimura et Migo
-
Regulation and role of extracellular polymeric substances in the defensive responses of Dictyosphaerium sp. to enrofloxacin stress
作者：Cheng, Qilu;Liu, Yangzhi;Ye, Jing;Wang, Qiang;Lin, Hui;Ma, Junwei;Xu, Ligen
关键词：Antibiotic; Hormesis effects; Toxic responses; Regulatory mechanism; Stress adaptation; Bioremediation
-
Determination of Biogenic Amines in Wine from Chinese Markets Using Ion Chromatography-Tandem Mass Spectrometry
作者：Zhu, Zuoyi;Jiang, Yunzhu;Yao, Jiarong;Li, Zhen;Dai, Fen;Wang, Qiang;Song, Xinyue
关键词：biogenic amines; wine; ion chromatography-tandem mass spectrometry; risk assessment
