Age-related changes of microbiota in midlife associated with reduced saccharolytic potential: an in vitro study
文献类型： 外文期刊
作者： Chen, Junkui 2 ; Pi, Xionge 2 ; Liu, Wei 2 ; Ding, Qunfang 1 ; Wang, Xin 2 ; Jia, Weiguo 1 ; Zhu, Liying 2 ;
作者机构： 1.Sichuan Univ, Ctr Gerontol & Geriatr, Natl Clin Res Ctr Geriatr, West China Hosp, Chengdu, Peoples R China
2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual, Inst Plant Protect & Microbiol, Hangzhou, Peoples R China
关键词： Midlife; Microbiota; In vitro fermentation; SCFAs; Acetate; Gas production
期刊名称：BMC MICROBIOLOGY （ 影响因子：3.605； 五年影响因子：4.283 ）
ISSN： 1471-2180
年卷期： 2021 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Background Gut microbiota is critical in maintaining human health, of which diversity and abundance are subject to significantly reduce in seniors. Gut microbiota is reported to be stable across the long adulthood in general, but lack of careful examination, especially for the midlife people. Results To characterize the gut microbiota in midlife, we investigated the faecal microbiota between two groups of healthy people, young, 20-39 years old, n = 15; and midlife, 40-60 years old, n = 15. Metabolic responses of the microbiota were studied through in vitro batch fermentation model. Although no difference was observed in the diversity indices between the two age groups, a wide range taxonomic changes were found in the faecal microbiota. Furthermore, substantial Bifidobacterium reduction was also found in both faecal and fermented samples. The faecal SCFAs are similar in both groups, as well as starch fermentation broth. However, after inulin fermentation, the acetate concentration and inulin degradation rate decreased while the gas production increased in midlife group, suggesting a deficiency of saccharolytic potential in midlife, especially for non-digestible carbohydrate. Conclusions Our data demonstrate that gut microbiota begins to change as early as in midlife. The reduction in Bifidobacterium dominates the change of the microbiota composition in midlife resulting in attenuated saccharolytic capacity of inulin, possibly leading to insufficient acetate production which might be associated with healthy problems in this transition period from young to elderly.
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