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Catechol functionalized chitosan/active peptide microsphere hydrogel for skin wound healing

文献类型： 外文期刊

作者： Zhang, Dongying 1 ; Ouyang, Qianqian 3 ; Hu, Zhang 1 ; Lu, Sitong 1 ; Quan, Weiyan 1 ; Li, Puwang 4 ; Chen, Yu 5 ; Li, Si 1 ;

作者机构： 1.Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

2.Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang 524000, Peoples R China

3.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China

4.Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524001, Peoples R China

5.Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

关键词： Chitosan; Active oyster peptide; Hydrogel; Wound healing

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2021 年 173 卷

页码：

收录情况： SCI

摘要： Chitosan-based thermosensitive hydrogels have been widely used in drug delivery and tissue engineering, but their poor bioactivity has limited their further applications. Integral active oyster peptide microspheres (OPM) with an average particle diameter of 3.9 mu m were prepared with high encapsulation efficiency (72.8%) and loading capacity (11.9%), exhibiting desirable sustained release effects. Using catechol functionalized chitosan (CS-C) as the polymeric matrix, OPM as the filler, and beta-sodium glycerophosphate (beta-GP) as a thermal sensitizer, the thermosensitive hydrogel CS-C/OPM/beta-GP was prepared. Besides, the application of the hydrogel on wound healing was studied, and its biosafety was evaluated. The results of cell migration in vitro showed that the cell migration rate of CS-C/OPM/beta-GP reached 97.47 +/- 5.41% within 48 h, indicating that the hydrogel accelerated the migration of L929 cells. As demonstrated in the mouse skin wound experiment, CS-C/OPM/beta-GP hydrogel not only inhibited the aggregation of diversified inflammatory cells and accelerated the generation of collagen fibers and new blood vessels of the wound, but also enhanced the synthesis of total protein (TP) in granulation tissue, and up-regulated the expression of Ki-67 and VEGF in the injury, thereby achieving fast wound healing. Safety evaluation results showed that CS-C/OPM/beta-GP hydrogel was not cytotoxic to L929 cells, and the hemolysis ratio was less than 5% within 1 mg/mL. In conclusion, CS-C/OPM/beta-GP hydrogel is expected as a promising medical dressing for wound healing. (C) 2021 Published by Elsevier B.V.

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