文献类型： 外文期刊
作者： Zhang, Qiaoyan 1 ; Wang, Xiajun 2 ; Wang, Qiang 2 ; Qi, Dake 3 ; Huang, Yali 3 ; Chen, Riping 3 ; Shan, Ying 1 ; Fang, Weihuan 1 ;
作者机构： 1.Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Zhejiang, Peoples R China
3.Hangzhou Med Coll, Sch Publ Hlth, Hangzhou 310013, Zhejiang, Peoples R China
关键词： Fipronil; Fipronil-sulfone; Laying hen; Egg residues; Pharmacokinetics
期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：5.19； 五年影响因子：5.053 ）
ISSN： 0944-1344
年卷期：
页码：
收录情况： SCI
摘要： Eighty 24-week-old laying hens were divided into eight groups, seven given a single oral dose per chicken with 7 dosing levels from 13.6 to 137 mg/kg body weight (bw) and one serving as sham control. The hens were observed for 28 days for clinical abnormalities, egg yield, and body weight. Egg samples from groups of low-to-medium doses were analyzed for residues of fipronil and its metabolites by LC-MS/MS. Blood and organ samples from hens of the group receiving 63.3 mg/kg bw were collected for hematochemical and histopathological analysis. We found that the median lethal dose (LD50) of fipronil was 74 mg/kg bw for laying hens. No death occurred, and there were no obvious changes in body weight and egg production in the hens receiving doses at or below 20 mg/kg bw. In the hens that survived exposure to the dose at 63.3 mg/kg bw, there was significant reduction in body weight and egg yield; histopathological changes in the liver and kidney; and increased levels of creatine, urea, glutamate oxaloacetate transferase, and glutamate pyruvic transaminase. Fipronil-sulfone was the residual marker in eggs with significantly higher concentrations and longer withdrawal periods than its maternal compound. We conclude that fipronil is efficiently transformed into fipronil-sulfone in the body with subsequent excretion into eggs. More attention should be paid to the potential food safety risk of fipronil-sulfone because of its persistence in eggs.
- 相关文献
作者其他论文 更多>>
-
Long-term phosphorus addition enhances the contributions of plant lignin and microbial necromass to soil organic carbon in a rice-wheat rotation
作者：Chen, Zhaoming;Ma, Jinchuan;Wang, Feng;Ma, Junwei;Zou, Ping;Sun, Wanchun;Yu, Qiaogang;Wang, Qiang
关键词：Lignin phenol; Microbial necromass; Soil organic carbon; Microbial diversity; Phosphorus fertilization; Paddy soil
-
Development of a certified reference material for accurate quantification of patulin in clear apple juice
作者：Zhang, Qiaoyan;Dai, Fen;Zhu, Zuoyi;Wang, Qiang;Zhang, Xiaofeng;Li, Ke;Xu, Jiaojiao
关键词：Certified reference material; Anti-browning; Patulin; Apple juice; ID-LC-MS/MS; Uncertainty
-
Nitrogen-induced acidification increases soil organic carbon accrual by promoting particulate organic carbon and microbial necromass under long-term experiments in the paddy soils of East China
作者：Chen, Zhaoming;Wang, Qiang;Ma, Jinchuan;Wang, Feng;Ma, Junwei;Ye, Jing;Zou, Ping;Sun, Wanchun;Yu, Qiaogang
关键词：Nitrogen fertilization; Mineral-associated organic carbon; Microbial necromass; Particulate organic carbon; Paddy soil
-
Acylated anthocyanins from Dendrobium officinale Kimura & Migo: Structural characteristics, antioxidant and hypoglycemic activities
作者：Zhu, Zuoyi;Huang, Yali;Jiang, Yunzhu;Yao, Jiarong;Li, Zhen;Dai, Fen;Song, Xinyue;Huang, Zhongping
关键词：Dendrobium officinale; Anthocyanin; Structure; Antioxidant activity; Hypoglycemic activity
-
Long-term biogas slurry application increases microbial necromass but not plant lignin contribution to soil organic carbon in paddy soils as regulated by fungal community
作者：Chen, Zhaoming;Ma, Jinchuan;Ma, Junwei;Ye, Jing;Yu, Qiaogang;Zou, Ping;Sun, Wanchun;Lin, Hui;Wang, Feng;Wang, Qiang;Zhao, Xinlin
关键词：Soil organic carbon; Lignin phenols; Microbial necromass; Microbial community structure; Biogas slurry
-
Long-term successive biochar application increases plant lignin and microbial necromass accumulation but decreases their contributions to soil organic carbon in rice-wheat cropping system
作者：Chen, Zhaoming;He, Lili;Ma, Jinchuan;Ma, Junwei;Ye, Jing;Yu, Qiaogang;Zou, Ping;Sun, Wanchun;Lin, Hui;Wang, Feng;Wang, Qiang;Zhao, Xu
关键词：amino sugars; biochar; lignin phenols; microbial necromass; paddy field; soil organic carbon
-
Tuning the Dynamic Reaction Balance of CRISPR/Cas12a and RPA in One Pot: A Key to Switch Nucleic Acid Quantification
作者：Yao, Zhihao;Wu, Qun;Yao, Zhihao;Xu, Yan;Wu, Qun;Yao, Zhihao;Xu, Yan;Wu, Qun;Yao, Zhihao;He, Kaiyu;Wang, Hongmei;Wang, Qiang;Xu, Xiahong;Wang, Liu;Yao, Zhihao;He, Kaiyu;Wang, Hongmei;Wang, Qiang;Xu, Xiahong;Wang, Liu;Feng, Suyin;Ding, Xiaoqing;Wang, Liu
关键词：quantification; CRISPR/Cas12a; isothermal amplification; nucleic acid; one pot
