文献类型： 外文期刊

作者： Guo, Xiao ¹ ; Cao, Xuedan ² ; Fang, Xiugui ² ; Guo, Ailing ¹ ; Li, Erhu ¹ ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, 1 Shizishan Rd, Wuhan 430070, Peoples R China

2.Zhejiang Acad Agr Sci, Zhejiang Citrus Res Inst, Taizhou, Peoples R China

关键词： Naringin; hesperidin; naringenin; hesperetin; bioavailability; phase II metabolism; efflux transportation

期刊名称：INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION （ 影响因子：4.444； 五年影响因子：4.37 ）

ISSN： 0963-7486

年卷期： 2022 年 73 卷 4 期

页码：

收录情况： SCI

摘要： This study examined the effects of phase II metabolism and efflux transportation on the bioavailability of naringin, hesperidin, and their aglycones (naringenin and hesperetin) in rats. Results indicated naringin and hesperidin have a lower oral bioavailability than their aglycones. Of all the phase II enzymes tested, UDP-glucuronosyltransferase (UGT) 1A1, UGT1A2, UGT1A3, UGT1A7 and SULT sulfotransferase (SULT) 1B1 were of minor importance regarding the phase II metabolism of naringenin and hesperetin in the small intestine. Naringin, hesperidin, and their aglycones were all extensively metabolised in the liver. Naringin and hesperidin were more extensively transported by efflux transporters compared to their aglycones. Significant correlations between phase II enzymes and efflux transporters were detected. In conclusion, more extensive metabolism of naringin and hesperidin than their aglycones in the small intestine, and the interplay of phase II enzymes and efflux transporters in the small intestine explain the lower relative oral bioavailability of naringin and hesperidin than their aglycones.