Factors influencing the effect of melatonin on sleep quality in children with autism spectrum disorder: a systematic review and meta-analysis
文献类型： 外文期刊
作者： Yang, Hao 1 ; Lu, Feng 2 ; Zhao, Xiaoyan 2 ;
作者机构： 1.Beijing Technol & Business Univ, Minist Educ, Key Lab Geriatr Nutr & Hlth, Beijing 100048, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing 100097, Peoples R China
3.Beijing Key Lab Fruits & Vegetable Storage & Proc, Beijing 100097, Peoples R China
4.Minist Agr & Rural Affairs, Key Lab Vegetable Postharvest Proc, Beijing 100097, Peoples R China
关键词： Melatonin; Autism; Children; Sleep quality; Meta-analysis
期刊名称：SLEEP AND BREATHING （ 影响因子：2.0； 五年影响因子：2.4 ）
ISSN： 1520-9512
年卷期： 2025 年 29 卷 4 期
页码：
收录情况： SCI
摘要： Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication. The prevalence of ASD has risen globally. Sleep disturbances exacerbates the core symptoms of children with ASD, and numerous studies demonstrated that melatonin is efficacious in treating autism-related insomnia in children. This study intended to comprehensively analyze the therapeutic effects of melatonin on sleep disturbances in children with autism, focusing on effect sizes across different treatment parameters, including medication dosage, type, treatment course, and the age of the children. Additionally, the analysis examines the effects of melatonin on various sleep indicators. Through systematic review and meta-analyses, data from existing studies were collected and categorizing them based on medication parameters and the age of the participants. The influence of melatonin on multiple sleep indicators was evaluated, revealing that melatonin significantly improves sleep quality and total sleep time in children with autism. The Hedges' g values for these two indicators were 0.75 and 0.58, with both P-values less than 0.05. The overall effect of melatonin displayed a parabolic relationship with dosage, achieving its optimal effectiveness at approximately 5.7 mg. Subject age also influenced the therapeutic effect with optimal results observed in children aged 10 years and older, where the Hedges' g effect size reached 0.09. Melatonin shows substantial effectiveness in improving the sleep in children with ASD, with minimal and mild adverse reactions. These findings support the development of individualized treatment approaches for melatonin administration in this population.
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