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Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance in Achromobacter sp. SMAs-55

文献类型： 外文期刊

作者： Yu, Yanshuang 1 ; Herzberg, Martin 3 ; Pat-Espadas, Aurora M. 4 ; Vinuesa, Pablo 5 ; Feng, Renwei 1 ; Rosen, Barry 6 ; Amachi, Seigo 7 ; Jia, Xianbo 2 ; Rensing, Christopher 1 ; Zhou, Shungui 1 ;

作者机构： 1.Fujian Agr & Forestry Univ, Coll Resources & Environm, Fuzhou 350002, Peoples R China

2.Fujian Acad Agr Sci, Inst Resources Environm & Soil Fertilizer, Fuzhou 350002, Peoples R China

3.UFZ Helmholtz Ctr Environm Res, Dept Solar Mat Biotechnol SOMA, D-04318 Leipzig, Germany

4.Univ Nacl Autonoma Mexico, CONAHCYT Inst Geol, Estn Reg Noroeste, Luis Donaldo Colosio S-N, Hermosillo 83250, Sonora, Mexico

5.Univ Nacl Autonoma Mexico, Ctr Ciencias Genom, Cuernavaca 62210, Morelos, Mexico

6.Florida Int Univ, Herbert Wertheim Coll Med, Dept Cellular Biol & Pharmacol, Miami, FL 33199 USA

7.Chiba Univ, Grad Sch Hort, Matsudo 2718510, Japan

关键词： Achromobacter; metalloids; antimony; arsenic; genome plasticity; transcriptome

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 1 期

页码：

收录情况： SCI

摘要： Microbes have been shown to adapt to stressful or even lethal conditions through displaying genome plasticity. However, how bacteria utilize the ability of genomic plasticity to deal with high antimony (Sb) stress has remained unclear. In this study, the spontaneous mutant strain SMAs-55 of Achromobacter sp. As-55 was obtained under antimonite (Sb(III)) stress. SMAs-55 displayed significantly increased Sb(III) resistance, but it lost the ability to oxidize arsenite (As(III)) by deleting an entire gene island containing genes encoding functions involved in As(III) oxidation, arsenic (As)/Sb resistance and phosphate transport. This study suggests that genetic plasticity has played an important role in As-55 adaption to Sb(III) stress. Transcriptomic analysis found that genes encoding functions involved in capsule polysaccharide synthesis, as well as functions correlated to stress adaptation, ATP production, and metabolism were more strongly expressed in SMAs-55. In addition, a lower intracellular Sb(III) accumulation in SMAs-55 was observed. These findings indicate that reduced uptake through increased capsule biosynthesis was an effective way for SMAs-55 to adapt to an environment displaying high levels of Sb. This study helps us to better understand the evolutionary processes enabling survival of microbes and microbial community in contaminated environments.

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