Comprehensive Study of Isocarbophos to Various Terrestrial Organisms: Enantioselective Bioactivity, Acute Toxicity, and Environmental Behaviors
文献类型： 外文期刊
作者： Di, Shanshan 1 ; Cang, Tao 1 ; Qi, Peipei 1 ; Wang, Zhiwei 1 ; Wang, Xiangyun 1 ; Xu, Mingfei 1 ; Wang, Xinquan 1 ; Xu, H 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
2.Agr Minist, Key Lab Pesticide Residue Detect, Hangzhou 310021, Zhejiang, Peoples R China
3.Key Lab Detect Pesticide Residues & Control Zheji, Hangzhou 310021, Zhejiang, Peoples R China
4.State Key Lab Qual & Safety Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
5.Desheng Middle Rd 298, Hangzhou 310021, Zhejiang, Peoples R China
关键词： isocarbophos; enantioselective bioactivity; enantioselective toxicity; toxicity interaction; bioaccumulation
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
ISSN： 0021-8561
年卷期： 2019 年 67 卷 40 期
页码：
收录情况： SCI
摘要： The enantioselective bioactivity, toxicity, and environmental behaviors of isocarbophos (ICP) were investigated. The order of the bioactivity and toxicity was S-(+) >= rac > R-(-), and the difference of R-(-) and S-(+) was up to 232 times. The usage of S-(+)-ICP may efficiently reduce the usage amount of rac-ICP by 35% under the same effect, and the toxicity was not increased. Based on the toxic unit analysis, the additive effect and synergistic effect of ICP enantiomers were found in the four nontarget organisms, and R-(-)-ICP might cooperate the side-effects of S-(+)-ICP. The accumulation of rac-ICP in earthworms was enantioselective with an enantioenrichment of R-(-)-ICP, so the usage of racemic ICP might increase the exposure risk of R-(-)-ICP to earthworms. From the comprehensive results, the production of enantiomer enriched S-(+)-ICP might increase bioactivity and reduce environmental pollution, while the toxicity of S-(+)-ICP to other nontarget organisms needs to be further assessed.
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