Design, Synthesis, and Antifungal Evaluation of Novel Quinoline Derivatives Inspired from Natural Quinine Alkaloids
文献类型： 外文期刊
作者： Yang, Guan-Zhou 1 ; Zhu, Jia-Kai 1 ; Yin, Xiao-Dan 1 ; Yan, Yin-Fang 1 ; Wang, Yu-Ling 2 ; Shang, Xiao-Fei 1 ; Liu, Yi 1 ;
作者机构： 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China
2.Gansu Acad Agr Sci, Lanzhou 730000, Gansu, Peoples R China
关键词： quinine; simplified structure; antifungal activity; Sclerotinia sclerotiorum
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
ISSN： 0021-8561
年卷期： 2019 年 67 卷 41 期
页码：
收录情况： SCI
摘要： Inspired by quinine and its analogues, we designed, synthesized, and evaluated two series of quinoline small molecular compounds (a and 2a) and six series of quinoline derivatives (3a-f) for their antifungal activities. The results showed that compounds 3e and 3f series exhibited significant fungicidal activities. Significantly, compounds 3f-4 (EC50 = 0.41 mu g/mL) and 3f-28 (EC50 = 0.55 mu g/mL) displayed the superior in vitro fungicidal activity and the potent in vivo curative effect against Sclerotinia sclerotiorum. Preliminary mechanism studies showed that compounds 3f-4 and 3f-28 could cause changes in the cell membrane permeability, accumulation of reactive oxygen species, loss of mitochondrial membrane potential, and effective inhibition of germination and formation of S. sclerotiorum sclerotia. These results indicate that compounds 3f-4 and 3f-28 are novel potential fungicidal candidates against S. sclerotiorum derived from natural products.
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