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Linc-GALMD1 Regulates Viral Gene Expression in the Chicken

文献类型： 外文期刊

作者： He, Yanghua 1 ; Han, Bo 2 ; Ding, Yi 2 ; Zhang, Huanmin 4 ; Chang, Shuang 4 ; Zhang, Li 6 ; Zhao, Chunfang 3 ; Yang, Ning 3 ;

作者机构： 1.Univ Hawaii Manoa, Dept Human Nutr Food & Anim Sci, Honolulu, HI 96822 USA

2.Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA

3.China Agr Univ, Coll Anim Sci & Technol, Dept Anim Genet & Breeding, Natl Engn Lab Anim Breeding, Beijing, Peoples R China

4.ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI USA

5.Shandong Agr Univ, Coll Vet Med, Tai An, Shandong, Peoples R China

6.Beijing Acad Agr & Forestry Sci, Inst Anim Sci & Vet Med, Beijing, Peoples R China

关键词： Linc-GALMD1; long intergenic non-coding ribonucleic acids; Marek's disease; Marek's disease virus; Chicken; Meq gene

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2019 年 10 卷

页码：

收录情况： SCI

摘要： A rapidly increasing number of reports on dysregulated long intergenic non-coding RNA (lincRNA) expression across numerous types of cancers indicates that aberrant lincRNA expression may be a major contributor to tumorigenesis. Marek's disease (MD) is a T cell lymphoma of chickens induced by Marek's disease virus (MDV). Although we have investigated the roles of lincRNAs in bursa tissue of MDV-infected chickens in previous studies, the molecular mechanisms of lincRNA functions in T cells remain poorly understood. In the present study, Linc-GALMD1 was identified from CD4+ T cells and MSB1 cells, and its expression was significantly downregulated in MD-resistant line of birds in response to MDV challenge. Furthermore, loss-of-function experiments indicated that linc-GALMD1 significantly affected the expression of 290 genes in trans. Through integrated analysis of differentially expressed genes (DEGs) induced by MDV and linc-GALMD1, we found that IGLL1 gene expression levels had a positive correlation with the degree of MD infection and could potentially serve as an indicator for clinical diagnosis of MD. Moreover, an interaction between MDV and linc-GALMD1 was also observed. Accordingly, chicken embryonic fibroblast cells were inoculated with MDV with and without the linc-GALMD1 knockdown, and the data showed that linc-GALMD1 could repress MDV gene expression during the course of MDV infection. These findings uncovered a role of linc-GALMD1 as a viral gene regulator and suggested a function of linc-GALMD1 contributing to tumor suppression by coordinating expression of MDV genes and tumor-related genes and regulating immune responses to MDV infection.

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