文献类型： 外文期刊
作者： Wang, Yanling 1 ; Yin, Yeshi 2 ; Chen, Xin 1 ; Zhao, Yongjia 1 ; Wu, Yichen 1 ; Li, Yifei 1 ; Wang, Xin 3 ; Chen, Huahai; 1 ;
作者机构： 1.Zhejiang Univ, Coll Med, Affiliated Hosp 1,State Key Lab Diag & Treatment, Natl Clin Res Ctr Infect Dis,Collaborat Innovat C, Hangzhou, Zhejiang, Peoples R China
2.Hunan Univ Sci & Engn, Coll Chem & Bioengn, Key Lab Comprehens Utilizat Advantage Plants Reso, Yongzhou, Peoples R China
3.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou, Zhejiang, Peoples R China
4.Zhejiang Acad Agr Sci, Key Lab Food Microbial Technol Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
关键词： segmented filamentous bacteria; flagellin; Th17 cells; IL-17A; SI EC
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）
ISSN： 1664-3224
年卷期： 2019 年 10 卷
页码：
收录情况： SCI
摘要： T-helper-17 (Th17) cells are a subset of CD4+ T cells that can produce the cytokine interleukin (IL)-17 and play vital roles in protecting the host from bacterial and fungal infections, especially at the mucosal surface. These are abundant in the small intestinal lamina propria (SILP) and their differentiation are associated with the colonization of the intestinal flora. Segmented filamentous bacteria (SFB) drew the attention of researchers due to their unique ability to drive the accumulation of Th17 cells in the SI LP of mice. Recent work has highlighted that SFB used microbial adhesion-triggered endocytosis (MATE) to transfer SFB antigenic proteins into small intestinal epithelial cells (SI ECs) and modulate host immune homeostasis. However, which components of SFB are involved in this immune response process remains unclear. Here, we examined the roles of SFB flagellins in Th17 cells induction using various techniques, including ELISA, ELISPOT, and RNA-seq in vitro and in vivo. The results show that the immune function of SFB flagellins is similar to SFB, i.e., induces the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the SI LP. Furthermore, treatment of mice with SFB flagellins lead to a significant increase in the expression of genes associated with the IL-17 signaling pathway, such as IL-6, IL-1 beta, TNF-alpha, IL-17A, IL-17F, and IL-22. In addition, SFB flagellins have an intimate relationship with intestinal epithelial cells, influencing the expression of epithelial cell-specific genes such as Nos2, Duox2, Duoxa2, SAA3, Tat, and Lcn2. Thus, we propose that SFB flagellins play a significant role in the involvement of SFB in the induction of intestinal Th17 cells.
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