Antibacterial mechanism of Tetrastigma hemsleyanum Diels et Gilg's polysaccharides by metabolomics based on HPLC/MS
文献类型： 外文期刊
作者： Chen, Xiao 1 ; Tao, Lan 1 ; Ru, Yi 1 ; Weng, Shaohuang 2 ; Chen, Zhou 2 ; Wang, Jian 1 ; Guo, Longhua 1 ; Lin, Zhenyu 1 ; Pa 1 ;
作者机构： 1.Fuzhou Univ, Fujian Prov Key Lab Anal & Detect Food Safety Eel, Key Lab Analyt Sci Food Safety & Biol, Minist Educ, Fuzhou 350108, Fujian, Peoples R China
2.Fujian Med Univ, Dept Pharm, Fuzhou 350007, Fujian, Peoples R China
3.Fujian Acad Agr Sci Fuzhou, Inst Agr Qual Stand & Testing Technol Res, Fuzhou 350003, Fujian, Peoples R China
关键词： Anti-bacterial activity; Metabonomics; Polysaccharides; Tetrastigma hemsleyanum Diels et Gilg
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2019 年 140 卷
页码：
收录情况： SCI
摘要： Tetrastigma hemsleyanum Diels et Gilg (THDG) is used as a Chinese traditional anti-inflammatory medicine for about thousands of years. In this work, Tetrastigma hemsleyanum Diels et Gilg's polysaccharide (TP) can inhibit E. coli's growth in initial dosing period. Compared with the antibacterial effect of Achyranthe's polysaccharide (AP) from their metabolic profile, it's obviously that their metabolic sites for E. coli were inconsistent. Moreover, TP could not only increase the level of fructose-6-phosphate (F6P), decrease the level of fructose-1,6-diphosphate (FBP), but also charge the amount of the two differential metabolic with the change of the concentration and the dosing time. Actually, F6P could transform into FBP by catalyze of 6-phosphofructokinase-1(6-PFK-1), which is an important process in glycolysis. Furthermore, FBP was considered have positively correlated with E. coifs growth rate. Therefore, TP can inhibit the E. coli's proliferation by interfering with the process for glycolysis and gluconeogenesis. Based on the experimental result, we proposed a new mouthwash method to evaluate the anti-bacterial activity. Compared with AP, TP can inhibit the E. coli's growth within 2 h with a low concentration (0.5%) and a short dosing time (5 min). This study extends the applications of THDG and establishes a new assessment method for the pharmacology activity of Chinese herbal medicine. (C) 2019 Elsevier B.V. All rights reserved.
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