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Changes of enzyme activity and gene expression in embryonic zebrafish co-exposed to beta-cypermethrin and thiacloprid

文献类型： 外文期刊

作者： Wang, Yanhua 1 ; Li, Xinfang 1 ; Yang, Guiling 1 ; Weng, Hongbiao 1 ; Wang, Xinquan 1 ; Wang, Qiang 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Qual & Safety Agroprod, Minist Agr,Inst Qual & Stand Agroprod, Key Lab Pesticide Residue Detect,Lab Hangzhou Ris, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Mixture toxicity; Danio rerio; Synergistic effect; Beta-cypermethrin; Thiacloprid

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2020 年 256 卷

页码：

收录情况： SCI

摘要： Pesticides often occur as mixtures of complex compounds in water environments, while most of studies only focus on the toxic effects of individual pesticides with little attention to the joint toxic effects. In the present study, we aimed to the mixture toxicity of beta-cypermethrin (BCY) and thiacloprid (THI) to zebrafish (Dank) rerio) employing multiple toxicological endpoints. Results displayed that the 96-h LC50 values of BCY to D. rerio at various developmental stages ranged from 2.64 x 10 (1.97 x 10-3.37 x 10) to 6.03 x 10(3) (4.54 x 10(3)-1.05 x 10(4)) nM, which were lower than those of THI ranging from 2.97 x 10(4) (1.96 x 10(4)-4.25 x 10(4)) to 2.86 x 10(5) (2.19 x 10 5 -5.87 x 10(5)) nM. Mixtures of BCY and THI exhibited synergistic response in embryonic zebrafish. Meanwhile, the enzyme activities of antioxidants (CAT and SOD) and detoxification enzyme (CarE), endogenous T-GSH and MDA contents, as well as gene expressions (tsh, crh, cxcl and bax) involved in oxidative stress, cellular apoptosis, immune system and endocrine system were obviously changed in the mixture exposure compared with the respective BCY or THI treatment. Consequently, the increased toxicity of pesticide mixture suggested that the toxicological data acquired from individual pesticide tests might underrate the toxicity risk of pesticides that actually arise in the real environment. Taken together, our present study provided evidence that mixture exposure of BCY and THI could induce additional toxic effect compared with their respective individual pesticides on D. rerio, offering valuable insights into the toxic mechanism of pesticide mixture. (C) 2019 Elsevier Ltd. All rights reserved.

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