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The interference of nonylphenol with bacterial cell-to-cell communication

文献类型： 外文期刊

作者： Jayaprada, Thilini 1 ; Hu, Jingming 1 ; Zhang, Yunyun 1 ; Feng, Huajun 1 ; Shen, Dongsheng 1 ; Geekiyanage, Sudarsh 1 ;

作者机构： 1.Zhejiang Gongshang Univ, Sch Environm Sci & Engn, Hangzhou 310012, Peoples R China

2.Zhejiang Prov Key Lab Solid Waste Treatment & Rec, Hangzhou 310012, Peoples R China

3.Univ Ruhuna, Dept Agr Biol, Mapalana 81100, Kamburupitiya, Sri Lanka

4.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizer, Hangzhou 310021, Peoples R China

关键词： Quorum sensing; Nonylphenol; Cell-to-cell communication; LasR protein

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2020 年 257 卷

页码：

收录情况： SCI

摘要： The interference of nonylphenol (NP) with humans and animals, especially in hormone systems, has been well-studied. There is rarely any record of its effect on bacteria, which dominate in various environments. In our study, we employed Pseudomonas aeruginosa PAO1 as a model microorganism and took its common lifestyle biofilm, mainly regulated by quorum sensing (QS), as a cut-in point to investigate the effect of NP (1, 5, 10 mg L-1) on bacteria. The results showed that more than 5 mg L-1 of NP did interfere with biofilm formation and affected bacterial QS. In detail, the LasI/R circuit, but not the RhII/R circuit, was considerably obstructed. The decrease in IasI and lasR expression resulted in a significant reduction in N-3-oxo-dodecanoyl homoserine lactone (3OC(12)-HSL) signals and the downstream production of elastases. Docking results indicated the binding of NP with LasR protein, simulating the binding of 3OC(12)-HSL with LasR protein, which explained the obstruction of the LasIR circuit. We concluded that NP competed with 3OC(12)-HSL and blocked 3OC(12)-HSL binding with the LasR protein, resulting in a direct interference in bacterial biofilm formation. This is the first report of NP interference with bacterial signaling, which is not only helpful to understand the effect of NP on various ecosystems, but is also beneficial to enrich our knowledge of inter-kingdom communication. (C) 2019 Elsevier Ltd. All rights reserved.

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