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Comparative Transcriptomic Analysis Reveals New Insights into Spawn Aging in Agaricus bisporus: Mitochondrial Dysfunction

文献类型： 外文期刊

作者： Shu, Lili 1 ; Zeng, Zhiheng 1 ; Chen, Meiyuan 1 ; Zhao, Jiazhi 2 ; Zhang, Xiaoyan 2 ; Dai, Jianqing 1 ; Cai, Zhixin 1 ; Lu, Yuanping 1 ; Qiu, Zhiheng 1 ; Zeng, Hui 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Edible Mushroom, Natl Local Joint Engn Res Ctr Breeding & Cultivat, Fuzhou 350011, Peoples R China

2.Shenyang Agr Univ, Coll Hort, Modern Protected Hort Engn & Technol Ctr, Shenyang 110866, Peoples R China

关键词： Agaricus bisporus; spawn aging; mitochondrial dysfunction; comparative transcriptome; molecular mechanisms

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 2 期

页码：

收录情况： SCI

摘要： Spawn aging poses a substantial challenge to the Agaricus bisporus industry. This study focuses on the role of mitochondrial dysfunction in the aging process of A. bisporus spawn. We conducted a comprehensive comparative transcriptome analysis to elucidate the molecular mechanisms underlying A. bisporus spawn aging. A total of 1620 genes with significant expression changes between the normal and aged spawn were identified, including 917 up-regulated genes and 703 down-regulated genes. Our results revealed a notable down-regulation of genes involved in carbohydrate metabolism, mitochondrial energy metabolism, reactive oxygen species (ROS) scavenging, repair mechanisms for oxidative stress-induced damage, fatty acid beta-oxidation, and amino acid degradation in aged A. bisporus spawn. Additionally, we observed a decreased expression of genes involved in critical signal transduction pathways associated with mitochondrial function in aged mycelium as well as genes responsible for maintaining mitochondrial stability. The up-regulated genes in aged spawn mainly affect mitochondrial fission and programmed cell death, impacting mitochondrial function. Overall, the present study first provides evidence for the pivotal role of mitochondrial dysfunction in the aging process of A. bisporus spawn and contributes to the development of targeted strategies to enhance mitochondrial function, mitigate spawn aging, and improve the yield and quality of A. bisporus cultivation.

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