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Potential of Milk-Derived Extracellular Vesicles as Carriers for Oral Delivery of Active Phytoconstituents

文献类型： 外文期刊

作者： Jiang, Qiao 1 ; Liu, Yubo 1 ; Si, Xu 1 ; Wang, Li 2 ; Gui, Hailong 1 ; Tian, Jinlong 1 ; Cui, Huijun 1 ; Jiang, Hongzhou 3 ; Dong, Wenjiang 4 ; Li, Bin 1 ;

作者机构： 1.Shenyang Agr Univ, Coll Food Sci, Shenyang, Peoples R China

2.Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China

3.Anhui Ziyue Biol Technol Co Ltd, Wuhu, Peoples R China

4.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning, Peoples R China

关键词： milk; extracellular vesicles; nanocarriers; oral delivery; active phytoconstituents; bioavailability

期刊名称：ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY （ 影响因子：10.6； 五年影响因子：13.7 ）

ISSN： 1941-1413

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Extracellular vesicles (EVs) play a crucial role in intercellular communication and have the potential to serve as in vivo carriers for delivering active molecules. The biocompatibility advantages of EVs over artificial nanocarriers create new frontiers for delivering modern active molecules. Milk is a favorable source of EVs because of its high bioavailability, low immunogenicity, and commercial producibility. In this review, we analyzed the advantages of milk-derived EVs in the oral delivery of active molecules, discussed their research progress in delivering active phytoconstituents, and summarized the necessary technologies and critical unit operations required for the development of an oral delivery system based on EVs. The review aims to provide innovative ideas and fundamental quality control guidelines for developing the next-generation oral drug delivery system based on milk-derived EVs.

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